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Independent association of HLA-DPB1*02:01 with rheumatoid arthritis in Japanese populations.

التفاصيل البيبلوغرافية
العنوان: Independent association of HLA-DPB1*02:01 with rheumatoid arthritis in Japanese populations.
المؤلفون: Hiroshi Furukawa, Shomi Oka, Kota Shimada, Atsushi Hashimoto, Akiko Komiya, Shinichiro Tsunoda, Akiko Suda, Satoshi Ito, Koichiro Saisho, Masao Katayama, Satoshi Shinohara, Takeo Sato, Katsuya Nagatani, Seiji Minota, Toshihiro Matsui, Naoshi Fukui, Shoji Sugii, Hajime Sano, Kiyoshi Migita, Shouhei Nagaoka, Shigeto Tohma
المصدر: PLoS ONE, Vol 13, Iss 9, p e0204459 (2018)
بيانات النشر: Public Library of Science (PLoS), 2018.
سنة النشر: 2018
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: OBJECTIVE:Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized with joint destructions; environmental and genetic factors were thought to be involved in the etiology of RA. The production of anti-citrullinated peptide antibodies (ACPA) is specifically associated with RA. DRB1 is associated with the susceptibility of RA, especially ACPA-positive RA [ACPA(+)RA]. However, a few studies reported on the independent associations of DPB1 alleles with RA susceptibility. Thus, we investigated the independent association of DPB1 alleles with RA in Japanese populations. METHODS:Association analyses of DPB1 were conducted by logistic regression analysis in 1667 RA patients and 413 controls. RESULTS:In unconditioned analysis, DPB1*04:02 was nominally associated with the susceptibility of ACPA(+)RA (P = 0.0021, corrected P (Pc) = 0.0275, odds ratio [OR] 1.52, 95% confidence interval [CI] 1.16-1.99). A significant association of DPB1*02:01 with the susceptibility of ACPA(+)RA was observed, when conditioned on DRB1 (Padjusted = 0.0003, Pcadjusted = 0.0040, ORadjusted 1.47, 95%CI 1.19-1.81). DPB1*05:01 was tended to be associated with the protection against ACPA(+)RA, when conditioned on DRB1 (Padjusted = 0.0091, Pcadjusted = 0.1184, ORadjusted 0.78, 95%CI 0.65-0.94). When conditioned on DRB1, the association of DPB1*04:02 with ACPA(+)RA was disappeared. No association of DPB1 alleles with ACPA-negative RA was detected. CONCLUSION:The independent association of DPB1*02:01 with Japanese ACPA(+)RA was identified.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC6157818?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0204459
URL الوصول: https://doaj.org/article/d084eed965fc45329765bc07f1513538
رقم الأكسشن: edsdoj.084eed965fc45329765bc07f1513538
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0204459