Desert areas of China have important ecological functions, so analyzing changing characteristics of ecosystem service values in this region is important for sustainable development. Using land use change data for desert areas from 1978 to 2022, this paper combined the equivalent factor method and the actual situation of the study area to revise value coefficients of ecosystem services and study characteristics of land use and ecosystem service value changes after reform and opening up. The results showed that after reform and opening up, the area of plow, water, and other lands in the study area decreased, while grassland, forest, construction land, and sandy land increased. The conversion of a land use type mainly occurred as conversion of grassland and other lands to other land use types. The value of ecosystem services increased, increasing by 19.63 × 108 CNY. From the perspective of land use type in 2022, the ecosystem service value of grassland was the highest, reaching 12.19 × 108 CNY, an increase of 11.73 × 108 CNY compared with the early stage of reform and opening up. From the perspective of ecosystem service types in 2022, the value of maintaining soil ecological services was the highest, reaching 3.07 × 108 CNY, an increase of 2.97 × 108 CNY compared with the beginning of reform and opening up. From the perspective of the ecological sensitivity index, the sensitivity index results for the ecosystem service value in the study area were all