دورية أكاديمية
أعرض في EDS

Clinicopathologic characteristics and outcomes of hepatocellular carcinoma associated with chronic hepatitis B versus hepatitis C infection

التفاصيل البيبلوغرافية
العنوان: Clinicopathologic characteristics and outcomes of hepatocellular carcinoma associated with chronic hepatitis B versus hepatitis C infection
المؤلفون: Abdulrahman A. Aljumah, Hadi Kuriry, Nabiha Faisal, Hamdan Alghamdi
المصدر: Annals of Saudi Medicine, Vol 38, Iss 5, Pp 358-365 (2018)
بيانات النشر: King Faisal Specialist Hospital and Research Centre, 2018.
سنة النشر: 2018
المجموعة: LCC:Medicine
مصطلحات موضوعية: Medicine
الوصف: BACKGROUND: Hepatocellular carcinoma (HCC) is a primary liver malignancy and one of the most common cancers worldwide. Few studies in Saudi Arabia have compared the clinicopathologic characteristics of HCC caused by hepatitis B virus (HBV) versus hepatitis C virus (HCV) and their effect on patient survival and prognosis. OBJECTIVES: Identify differences in clinicopathological characteristics and outcomes of hepatocellular carcinoma (HCC) caused by HBV versus HCV. DESIGN: A retrospective medical records review. SETTING: Tertiary medical center in Riyadh. PATIENTS AND METHODS: We included all new cases of HCC with underlying HBV and HCV infection diagnosed between January 2013 and September 2017 that met inclusion criteria. MAIN OUTCOME MEASURES: Clinical, biochemical, pathological and radiological characteristics, and survival differences were compared between HCC that developed in HBV- and HCV-infected patients. SAMPLE SIZE: Of 253 patients evaluated, 172 patients were included in the study. RESULTS: Of the 172 patients, 110 (64%) had HCV-associated HCC and 62 (36%) had HBV-associated HCC. More patients with HBV infection were males (P=.003) and were younger (P=.015) than HCV patients. HCV-infected patients who developed HCC had more advanced cirrhosis (P=.048). The prevalence of comorbidities and pre-existing cirrhosis was similar in both groups. Seven patients (6.8%) with underlying HCV developed HCC in the absence of cirrhosis. Patients with HBV-associated HCC were less likely to meet Milan criteria at initial diagnosis than those with HCV-associated HCC (33.9% vs. 52.7%, respectively, P=.017). HBV-associated HCC occurred at a more advanced Barcelona Clinic Liver Cancer stage. The overall median survival and treatment outcome for each modality was comparable. CONCLUSIONS: HBV- and HCV-associated HCC have distinct clinical and pathological characteristics, necessitating different screening policies to optimize HCC surveillance and management. However, viral etiology did not affect the treatment outcome and long-term survival. LIMITATIONS: Conducted in a single-center, retrospective and lacks information about the use of antiviral treatment. CONFLICT OF INTEREST: None.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 0256-4947
0975-4466
24254134
Relation: https://doaj.org/toc/0256-4947; https://doaj.org/toc/0975-4466
DOI: 10.5144/0256-4947.2018.358
URL الوصول: https://doaj.org/article/e0a0e24254134a69ac53ae45299f95d5
رقم الأكسشن: edsdoj.0a0e24254134a69ac53ae45299f95d5
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:02564947
09754466
24254134
DOI:10.5144/0256-4947.2018.358