دورية أكاديمية
Decreased placental IL9 and IL9R in preeclampsia impair trophoblast cell proliferation, invasion, and angiogenesis
| العنوان: | Decreased placental IL9 and IL9R in preeclampsia impair trophoblast cell proliferation, invasion, and angiogenesis |
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| المؤلفون: | Yi Sun, Siyu Liu, Rong Hu, Qiongjie Zhou, Xiaotian Li |
| المصدر: | Hypertension in Pregnancy, Vol 39, Iss 3, Pp 228-235 (2020) |
| بيانات النشر: | Taylor & Francis Group, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Gynecology and obstetrics |
| مصطلحات موضوعية: | il9, il9 receptor, trophoblast, biological behaviors, Gynecology and obstetrics, RG1-991 |
| الوصف: | Objective Our study aimed to investigate IL9 and IL9R expression in preeclampsia and assess their effects on trophoblast biological behaviors. Methods IL9 and IL9R expression of placenta tissue were evaluated by immunochemistry and q-PCR. Using transwell, CCK-8, and tubule formation assays measured invasion, proliferation and angiogenesis of trophoblast with adding IL9 or anti-IL9R antibody. Results IL9 and IL9R levels were significantly decreased in preeclampsia. IL9 improved trophoblast activities. Blocking IL9/IL9R resulted in decreased proliferation, invasion, and tube-formation capability of trophoblast. Conclusions IL9 and IL9R contribute to the pathogenesis of preeclampsia. IL9/IL9R signaling provides a new potential therapeutic target for preventing preeclampsia. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1064-1955 1525-6065 10641955 68616724 |
| Relation: | https://doaj.org/toc/1064-1955; https://doaj.org/toc/1525-6065 |
| DOI: | 10.1080/10641955.2020.1754852 |
| URL الوصول: | https://doaj.org/article/a0a68616724e4bff855e93f82bebb299 |
| رقم الأكسشن: | edsdoj.0a68616724e4bff855e93f82bebb299 |
| قاعدة البيانات: | Directory of Open Access Journals |
PDF full text from Publisher | تدمد: | 10641955 15256065 68616724 |
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| DOI: | 10.1080/10641955.2020.1754852 |