دورية أكاديمية
Comparative Investigation of Gene Regulatory Processes Underlying Avian Influenza Viruses in Chicken and Duck
العنوان: | Comparative Investigation of Gene Regulatory Processes Underlying Avian Influenza Viruses in Chicken and Duck |
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المؤلفون: | Selina Klees, Johanna-Sophie Schlüter, Jendrik Schellhorn, Hendrik Bertram, Antje Christine Kurzweg, Faisal Ramzan, Armin Otto Schmitt, Mehmet Gültas |
المصدر: | Biology, Vol 11, Iss 2, p 219 (2022) |
بيانات النشر: | MDPI AG, 2022. |
سنة النشر: | 2022 |
المجموعة: | LCC:Biology (General) |
مصطلحات موضوعية: | avian influenza, chicken, duck, mallard, gene regulation, differentially expressed genes, Biology (General), QH301-705.5 |
الوصف: | The avian influenza virus (AIV) mainly affects birds and not only causes animals’ deaths, but also poses a great risk of zoonotically infecting humans. While ducks and wild waterfowl are seen as a natural reservoir for AIVs and can withstand most virus strains, chicken mostly succumb to infection with high pathogenic avian influenza (HPAI). To date, the mechanisms underlying the susceptibility of chicken and the effective immune response of duck have not been completely unraveled. In this study, we investigate the transcriptional gene regulation underlying disease progression in chicken and duck after AIV infection. For this purpose, we use a publicly available RNA-sequencing dataset from chicken and ducks infected with low-pathogenic avian influenza (LPAI) H5N2 and HPAI H5N1 (lung and ileum tissues, 1 and 3 days post-infection). Unlike previous studies, we performed a promoter analysis based on orthologous genes to detect important transcription factors (TFs) and their cooperation, based on which we apply a systems biology approach to identify common and species-specific master regulators. We found master regulators such as EGR1, FOS, and SP1, specifically for chicken and ETS1 and SMAD3/4, specifically for duck, which could be responsible for the duck’s effective and the chicken’s ineffective immune response. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2079-7737 |
Relation: | https://www.mdpi.com/2079-7737/11/2/219; https://doaj.org/toc/2079-7737 |
DOI: | 10.3390/biology11020219 |
URL الوصول: | https://doaj.org/article/0afc418cc268484d88859a4f01960efe |
رقم الأكسشن: | edsdoj.0afc418cc268484d88859a4f01960efe |
قاعدة البيانات: | Directory of Open Access Journals |
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