Objectives: To estimate the prevalence, knowledge and lifestyle association with acne among medical students at King Saud University, Riyadh, Kingdom of Saudi Arabia. Methods: This quantitative, observational and cross-sectional study was conducted among medical students in March 2015 by using self-administered questionnaire survey. Statistical analysis was performed using p-value. Results: A total of three hundred and seventy-five medical students were recruited, and more than half of them had acne vulgaris (n: 208; 55.5%) with less than one third of them being diagnosed by a physician. Most of the female students (n: 75; 61%) dealt with acne as a significant medical condition when compared with only third (n: 87; 34%) of the male students (P 0.05). One hundred and twelve male students (44.8%) believed more than females (n: 39; 31%) that acne affects their marriage prospectus p
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