دورية أكاديمية
The Role of KRAS Mutation in Colorectal Cancer-Associated Thrombosis
| العنوان: | The Role of KRAS Mutation in Colorectal Cancer-Associated Thrombosis |
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| المؤلفون: | Radu Andrei Emilescu, Mariana Jinga, Horia Teodor Cotan, Ana Maria Popa, Cristina Maria Orlov-Slavu, Mihaela Cristina Olaru, Cristian Ion Iaciu, Andreea Ioana Parosanu, Mihaela Moscalu, Cornelia Nitipir |
| المصدر: | International Journal of Molecular Sciences, Vol 24, Iss 23, p 16930 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | molecular subtypes, arterial and venous thrombosis, KRAS, colorectal cancer, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Venous thromboembolic events (VTE) are common in patients with colorectal cancer (CRC) and represent a significant contributor to morbidity and mortality. Risk stratification is paramount in deciding the initiation of thromboprophylaxis and is calculated using scores that include tumor location, laboratory values, patient clinical characteristics, and tumor burden. Commonly used risk scores do not include the presence of molecular aberrations as a variable. This retrospective study aims to confirm the link between KRAS-activating mutations and the development of VTE in CRC. A total of 166 patients were included in this study. They were split into two cohorts based on KRAS mutational status. We evaluated the frequency and mean time to VTE development stratified by the presence of KRAS mutations. Patients with mutant KRAS had an odds ratio (OR) of 2.758 for VTE compared to KRAS wild-type patients, with an increased risk of thrombosis being maintained in KRAS mutant patients even after adjusting for other known VTE risk factors. Taking into account the results of this study, KRAS mutation represents an independent risk factor for VTE. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/24/23/16930; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms242316930 |
| URL الوصول: | https://doaj.org/article/0badf982e66d4f579d9267c64f187ed3 |
| رقم الأكسشن: | edsdoj.0badf982e66d4f579d9267c64f187ed3 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms242316930 |