دورية أكاديمية
Optimizing cord blood thyroid stimulating hormone cutoff for screening of congenital hypothyroidism—experience from screening 164,000 newborns in a tertiary hospital in India
| العنوان: | Optimizing cord blood thyroid stimulating hormone cutoff for screening of congenital hypothyroidism—experience from screening 164,000 newborns in a tertiary hospital in India |
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| المؤلفون: | Praveen G Paul, Grace Rebekah, Sophy Korula, Manish Kumar, Joseph D Bondu, Raghupathy Palany, Anna Simon, Sarah Mathai |
| المصدر: | Indian Journal of Endocrinology and Metabolism, Vol 25, Iss 4, Pp 348-353 (2021) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: | congenital hypothyroidism, cord blood, newborn screening, tsh, Diseases of the endocrine glands. Clinical endocrinology, RC648-665, Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: | Background and Objectives: In our institution, we have an ongoing newborn thyroid screening (NBS) program since July 2001. In the initial 9 months, we used cord blood thyroid-stimulating hormone (TSH) (CBTSH) cutoff of 20 mIU/L and thereafter the cutoff was increased to 25 mIU/L. Our objective was to evaluate whether a CBTSH cutoff of 25 mIU/L is sensitive and cost-effective in NBS of congenital hypothyroidism (CH). Materials and Methods: All in-born babies are screened and those with CBTSH ≥25 mIU/L are recalled for confirmatory TSH/T4/FT4 tests. CH is confirmed with elevated TSH and low T4/FT4. Those with CBTSH 20–24.99 mIU/L were recalled for confirmatory tests in initial period of our NBS and prospectively between January and August 2017. Statistical analysis was done to derive positive predictive value and sensitivity to diagnose CH for each CBTSH between 20 and 30 mIU/L. Results: A total of 164,163 neonates were screened from July 2001 to August 2017. Of the 2352 babies with CBTSH ≥25–30 mIU/L, 1763 returned for retesting and 5 confirmed as CH (4 gland-in-situ and 1 absent uptake on nuclear scan). Of the 14,742 screened during the study period, 195 of the 293 babies with CBTSH 20–24.99 mIU/L returned for retesting and none diagnosed as CH. A CBTSH of 25 mIU/L has 99.2% sensitivity and 97.5% specificity. A lower screen TSH cutoff 20 mIU/L would result in recall of additional 300 babies/year with no definite improvement in sensitivity. Conclusions: Our data justify the continuation of using screen TSH cutoff of 25 mIU/L while using cord blood for NBS in our population. With a diverse and large population, it is important that we use feasible regional screen cutoffs for optimal use of our resources. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2230-8210 |
| Relation: | http://www.ijem.in/article.asp?issn=2230-8210;year=2021;volume=25;issue=4;spage=348;epage=353;aulast=Paul; https://doaj.org/toc/2230-8210 |
| DOI: | 10.4103/ijem.ijem_220_21 |
| URL الوصول: | https://doaj.org/article/0c67d954fdc94c5a87c6ddbac1ed5ee1 |
| رقم الأكسشن: | edsdoj.0c67d954fdc94c5a87c6ddbac1ed5ee1 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22308210 |
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| DOI: | 10.4103/ijem.ijem_220_21 |