دورية أكاديمية
Intestinal epithelial cell-derived components regulate transcriptome of Lactobacillus rhamnosus GG
العنوان: | Intestinal epithelial cell-derived components regulate transcriptome of Lactobacillus rhamnosus GG |
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المؤلفون: | Kasey Schalich, Seesandra Rajagopala, Suman Das, Ryan O’Connell, Fang Yan |
المصدر: | Frontiers in Microbiology, Vol 13 (2023) |
بيانات النشر: | Frontiers Media S.A., 2023. |
سنة النشر: | 2023 |
المجموعة: | LCC:Microbiology |
مصطلحات موضوعية: | bacterial transporter, bacterial metabolism, commensal bacterium, intestinal epithelial cell, RNA sequencing, the microbial-host interaction, Microbiology, QR1-502 |
الوصف: | IntroductionIntestinal epithelial cells (IECs) provide the frontline responses to the gut microbiota for maintaining intestinal homeostasis. Our previous work revealed that IEC-derived components promote the beneficial effects of a commensal and probiotic bacterium, Lactobacillus rhamnosus GG (LGG). This study aimed to elucidate the regulatory effects of IEC-derived components on LGG at the molecular level.MethodsDifferential gene expression in LGG cultured with IEC-derived components at the timepoint between the exponential and stationary phase was studied by RNA sequencing and functional analysis.ResultsThe transcriptomic profile of LGG cultured with IEC-derived components was significantly different from that of control LGG, with 231 genes were significantly upregulated and 235 genes significantly down regulated (FDR |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1664-302X |
Relation: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.1051310/full; https://doaj.org/toc/1664-302X |
DOI: | 10.3389/fmicb.2022.1051310 |
URL الوصول: | https://doaj.org/article/0ecdead976da4247bafc8aeef2318c34 |
رقم الأكسشن: | edsdoj.0ecdead976da4247bafc8aeef2318c34 |
قاعدة البيانات: | Directory of Open Access Journals |
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