دورية أكاديمية
Involvement of memory T-cells in the pathophysiology of chronic lymphocytic leukemia
| العنوان: | Involvement of memory T-cells in the pathophysiology of chronic lymphocytic leukemia |
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| المؤلفون: | Rodolfo Patussi Correia, Flavia Amoroso Matos e Silva, Nydia Strachman Bacal, Paulo Vidal Campregher, Nelson Hamerschlak, Gustavo P. Amarante-Mendes |
| المصدر: | Revista Brasileira de Hematologia e Hemoterapia, Vol 36, Iss 1, Pp 60-64 (2014) |
| بيانات النشر: | Elsevier, 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Diseases of the blood and blood-forming organs |
| مصطلحات موضوعية: | Leukemia lymphocytic chronic, B-cell, T-lymphocytes, Immunologic memory, Diseases of the blood and blood-forming organs, RC633-647.5 |
| الوصف: | The role of T-cells in the pathogenesis of chronic lymphocytic leukemia has recently gained much attention due to the importance of the constant interaction between neoplastic B-cells with microenvironment substratum and T-cells. It is believed that these interactions modulate the clinical course of the disease, mainly through the regulation of the expansion, differentiation, and survival of chronic lymphocytic leukemia B-cells. Importantly, this crosstalk may also change the number, function, and memory phenotype of normal T-cells, thereby altering the amplitude and/or efficiency of adaptive immunity in chronic lymphocytic leukemia patients. The present study presents an overview on important aspects of this immunological crosstalk, particularly on the abnormalities of chronic lymphocytic leukemia B-cells and the alterations in normal T-cells, with focus on the CD4 memory T-cell compartment that could offer survival signals to chronic lymphocytic leukemia B-cell clone(s) and contribute to the establishment and progression of the disease. The authors believe that understanding the biological consequences of the interaction between normal T- and neoplastic B-cells in chronic lymphocytic leukemia may allow for improvements in the prognostic information and therapeutic approaches for this disease. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1806-0870 1516-8484 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842014000100060&lng=en&tlng=en; https://doaj.org/toc/1806-0870 |
| DOI: | 10.5581/1516-8484.20140015 |
| URL الوصول: | https://doaj.org/article/ca1091d6dbe74cd797671bd9fd60df44 |
| رقم الأكسشن: | edsdoj.1091d6dbe74cd797671bd9fd60df44 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 18060870 15168484 |
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| DOI: | 10.5581/1516-8484.20140015 |