دورية أكاديمية
PhyloMed: a phylogeny-based test of mediation effect in microbiome
| العنوان: | PhyloMed: a phylogeny-based test of mediation effect in microbiome |
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| المؤلفون: | Qilin Hong, Guanhua Chen, Zheng-Zheng Tang |
| المصدر: | Genome Biology, Vol 24, Iss 1, Pp 1-21 (2023) |
| بيانات النشر: | BMC, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) LCC:Genetics |
| مصطلحات موضوعية: | Composite null hypothesis, Mediation analysis, Microbiome, Phylogenetic tree, Biology (General), QH301-705.5, Genetics, QH426-470 |
| الوصف: | Abstract Microbiome data from sequencing experiments contain the relative abundance of a large number of microbial taxa with their evolutionary relationships represented by a phylogenetic tree. The compositional and high-dimensional nature of the microbiome mediator challenges the validity of standard mediation analyses. We propose a phylogeny-based mediation analysis method called PhyloMed to address this challenge. Unlike existing methods that directly identify individual mediating taxa, PhyloMed discovers mediation signals by analyzing subcompositions defined on the phylogenic tree. PhyloMed produces well-calibrated mediation test p-values and yields substantially higher discovery power than existing methods. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1474-760X |
| Relation: | https://doaj.org/toc/1474-760X |
| DOI: | 10.1186/s13059-023-02902-3 |
| URL الوصول: | https://doaj.org/article/e10962af308a4cd7adae623cfb5fa1a5 |
| رقم الأكسشن: | edsdoj.10962af308a4cd7adae623cfb5fa1a5 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1474760X |
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| DOI: | 10.1186/s13059-023-02902-3 |