دورية أكاديمية
Hair Growth Regulation by Fibroblast Growth Factor 12 (FGF12)
| العنوان: | Hair Growth Regulation by Fibroblast Growth Factor 12 (FGF12) |
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| المؤلفون: | Jiwon Woo, Wonhee Suh, Jong-Hyuk Sung |
| المصدر: | International Journal of Molecular Sciences, Vol 23, Iss 16, p 9467 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | fibroblast growth factor 12, hair growth, anagen induction, outer root sheath cell, cell migration, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | The fibroblast growth factor (FGF) family has various biological functions, including cell growth, tissue regeneration, embryonic development, metabolism, and angiogenesis. In the case of hair growth, several members of the FGF family, such as FGF1 and FGF2, are involved in hair growth, while FGF5 has the opposite effect. In this study, the regulation of the hair growth cycle by FGF12 was investigated. To observe its effect, the expression of FGF12 was downregulated in mice and outer root sheath (ORS) by siRNA transfection, while FGF12 overexpression was carried out using FGF12 adenovirus. For the results, FGF12 was primarily expressed in ORS cells with a high expression during the anagen phase of hair follicles. Knockdown of FGF12 delayed telogen-to-anagen transition in mice and decreased the hair length in vibrissae hair follicles. It also inhibited the proliferation and migration of ORS cells. On the contrary, FGF12 overexpression increased the migration of ORS cells. FGF12-overexpressed ORS cells induced the telogen-to-anagen transition in the animal model. In addition, FGF12 overexpression regulated the expression of PDGF-CC, MDK, and HB-EGF, and treatment of these factors exhibited hair growth promotion. Altogether, FGF12 promoted hair growth by inducing the anagen phase of hair follicles, suggesting the potential for hair loss therapy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 47728035 |
| Relation: | https://www.mdpi.com/1422-0067/23/16/9467; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms23169467 |
| URL الوصول: | https://doaj.org/article/10b3ede9387d477280352b98a7e496df |
| رقم الأكسشن: | edsdoj.10b3ede9387d477280352b98a7e496df |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 47728035 |
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| DOI: | 10.3390/ijms23169467 |