دورية أكاديمية
Inorganic Nanozyme with Combined Self-Oxygenation/Degradable Capabilities for Sensitized Cancer Immunochemotherapy
| العنوان: | Inorganic Nanozyme with Combined Self-Oxygenation/Degradable Capabilities for Sensitized Cancer Immunochemotherapy |
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| المؤلفون: | Jie Wang, Lan Fang, Ping Li, Lang Ma, Weidan Na, Chong Cheng, Yueqing Gu, Dawei Deng |
| المصدر: | Nano-Micro Letters, Vol 11, Iss 1, Pp 1-18 (2019) |
| بيانات النشر: | SpringerOpen, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Technology |
| مصطلحات موضوعية: | Inorganic nanozyme, Self-oxygenation nanoreactor, Biodegradable nanomedicine, Immunochemotherapy, Cancer treatment, Technology |
| الوصف: | Abstract Recently emerged cancer immunochemotherapy has provided enormous new possibilities to replace traditional chemotherapy in fighting tumor. However, the treatment efficacy is hampered by tumor hypoxia-induced immunosuppression in tumor microenvironment (TME). Herein, we fabricated a self-oxygenation/degradable inorganic nanozyme with a core–shell structure to relieve tumor hypoxia in cancer immunochemotherapy. By integrating the biocompatible CaO2 as the oxygen-storing component, this strategy is more effective than the earlier designed nanocarriers for delivering oxygen or H2O2, and thus provides remarkable oxygenation and long-term capability in relieving hypoxia throughout the tumor tissue. Consequently, in vivo tests validate that the delivery system can successfully relieve hypoxia and reverse the immunosuppressive TME to favor antitumor immune responses, leading to enhanced chemoimmunotherapy with cytotoxic T lymphocyte-associated antigen 4 blockade. Overall, a facile, robust and effective strategy is proposed to improve tumor oxygenation by using self-decomposable and biocompatible inorganic nanozyme reactor, which will not only provide an innovative pathway to relieve intratumoral hypoxia, but also present potential applications in other oxygen-favored cancer therapies or oxygen deficiency-originated diseases. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2311-6706 2150-5551 |
| Relation: | http://link.springer.com/article/10.1007/s40820-019-0305-x; https://doaj.org/toc/2311-6706; https://doaj.org/toc/2150-5551 |
| DOI: | 10.1007/s40820-019-0305-x |
| URL الوصول: | https://doaj.org/article/a13c4cab9537478ba3b737f29d86187f |
| رقم الأكسشن: | edsdoj.13c4cab9537478ba3b737f29d86187f |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 23116706 21505551 |
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| DOI: | 10.1007/s40820-019-0305-x |