N 1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism

التفاصيل البيبلوغرافية
العنوان:	N 1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism
المؤلفون:	Yanying Wang, Jing Wang, Xiaoyu Li, Xushen Xiong, Jianyi Wang, Ziheng Zhou, Xiaoxiao Zhu, Yang Gu, Dan Dominissini, Lei He, Yong Tian, Chengqi Yi, Zusen Fan
المصدر:	Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
بيانات النشر:	Nature Portfolio, 2021.
سنة النشر:	2021
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	Metabolic adaptation has been reported to promote cancer, yet the underlying mechanisms are not clear. Here, the authors show that m1A methylation in tRNA regulates cholesterol metabolism in liver cancer stem cells and m1A inhibition decreases tumourigenesis in preclinical models of hepatocellular carcinoma.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/s41467-021-26718-6
URL الوصول:	https://doaj.org/article/13c5a25590da4573bc3cc56bbda89738
رقم الأكسشن:	edsdoj.13c5a25590da4573bc3cc56bbda89738
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-021-26718-6