دورية أكاديمية
The Intake of Coffee Increases the Absorption of Aspirin in Mice by Modifying Gut Microbiome
| العنوان: | The Intake of Coffee Increases the Absorption of Aspirin in Mice by Modifying Gut Microbiome |
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| المؤلفون: | Jeon-Kyung Kim, Min Sun Choi, Hye Hyun Yoo, Dong-Hyun Kim |
| المصدر: | Pharmaceutics, Vol 14, Iss 4, p 746 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | aspirin, salicylic acid, pharmacokinetic, gut microbiome, Mrp4, Pharmacy and materia medica, RS1-441 |
| الوصف: | The absorption of orally administered aspirin into the blood was affected by gastrointestinal environmental factors such as gut pH, digestive enzymes, and microbiota. The intake of coffee affects the pharmacological effects of aspirin. Therefore, we examined the gut microbiota-mediated effect of coffee bean extract (CBE) intake on the pharmacokinetics of aspirin in mice. The intake of CBE modified the gut microbiota composition and their α- and β-diversities: It decreased the Proteobacteria, Helicobacteriaceae, and Bacteroidaceae populations in the fecal microbiota composition, while the S24-7_f (Muribaculaceae) and Lactobacillaceae populations increased. The fecal aspirin-hydrolyzing activities of humans and mice to salicylic acid were 0.045 ± 0.036 μmole/h/g and 0.032 ± 0.003 μmole/h/g, respectively. However, CBE treatment significantly suppressed the aspirin-hydrolyzing activity in mice. Furthermore, the area under the serum concentration–time curves (AUCs) of aspirin and salicylic acid were 0.265 ± 0.050 µg·h/mL and 16.224 ± 5.578 µg·h/mL in CBE-treated mice, respectively, and 0.248 ± 0.042 µg·h/mL and 10.756 ± 2.071 µg·h/mL in control mice, respectively. Moreover, CBE treatment suppressed the multidrug resistance protein 4 (Mrp4) expression in the intestines of mice, while the P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) expression was not affected. Furthermore, the CBE-treated mouse fecal lysate suppressed Mrp4 expression in Caco-2 cells compared to that of vehicle-treated mice, while CBE treatment did not affect Mrp4 expression. Oral gavage of caffeine also suppressed the Mrp4 expression in the intestines of mice. These findings suggest that intake of coffee can increase the absorption of aspirin by modifying the gut microbiome. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1999-4923 40108988 |
| Relation: | https://www.mdpi.com/1999-4923/14/4/746; https://doaj.org/toc/1999-4923 |
| DOI: | 10.3390/pharmaceutics14040746 |
| URL الوصول: | https://doaj.org/article/149488f3da6d401089886adef52dd319 |
| رقم الأكسشن: | edsdoj.149488f3da6d401089886adef52dd319 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19994923 40108988 |
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| DOI: | 10.3390/pharmaceutics14040746 |