دورية أكاديمية
Potential of Lycii Radicis Cortex as an Ameliorative Agent for Skeletal Muscle Atrophy
| العنوان: | Potential of Lycii Radicis Cortex as an Ameliorative Agent for Skeletal Muscle Atrophy |
|---|---|
| المؤلفون: | Rak Ho Son, Myeong Il Kim, Hye Mi Kim, Shuo Guo, Do Hyun Lee, Gyu Min Lim, Seong-Min Kim, Jae-Yong Kim, Chul Young Kim |
| المصدر: | Pharmaceuticals, Vol 17, Iss 4, p 462 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | Lycii Radicis Cortex, muscle atrophy, C2C12 myotubes, dexamethasone, protein degradation, protein synthesis, Medicine, Pharmacy and materia medica, RS1-441 |
| الوصف: | Lycii Radicis Cortex (LRC) is a traditional medicine in East Asia with various beneficial effects, including antioxidant, anti-inflammatory, anti-tumor, anti-diabetic, and anti-depressant properties. However, its potential effects on skeletal muscle atrophy have not been studied. In this study, the protective effects of LRC extract (LRCE) on dexamethasone (DEX)-induced muscle atrophy were investigated in C2C12 myotubes and mice. We evaluated the effect of LRCE on improving muscle atrophy using a variety of methods, including immunofluorescence staining, quantitative polymerase chain reaction (qPCR), Western blot, measurements of oxidative stress, apoptosis, ATP levels, and muscle tissue analysis. The results showed that LRCE improved myotube diameter, fusion index, superoxide dismutase (SOD) activity, mitochondrial content, ATP levels, expression of myogenin and myosin heavy chain (MHC), and reduced reactive oxygen species (ROS) production in dexamethasone-induced C2C12 myotubes. LRCE also enhanced protein synthesis and reduced protein degradation in the myotubes. In mice treated with DEX, LRCE restored calf thickness, decreased mRNA levels of muscle-specific RING finger protein 1 (MuRF1) and atrogin-1, and increased insulin-like growth factor 1 (IGF-1) mRNA level. Moreover, LRCE also repaired gastrocnemius muscle atrophy caused by DEX. Although human studies are not available, various preclinical studies have identified potential protective effects of LRCE against muscle atrophy, suggesting that it could be utilized in the prevention and treatment of muscle atrophy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1424-8247 |
| Relation: | https://www.mdpi.com/1424-8247/17/4/462; https://doaj.org/toc/1424-8247 |
| DOI: | 10.3390/ph17040462 |
| URL الوصول: | https://doaj.org/article/e14ec06ef28240f5b6a39ec389bb4afb |
| رقم الأكسشن: | edsdoj.14ec06ef28240f5b6a39ec389bb4afb |
| قاعدة البيانات: | Directory of Open Access Journals |
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