دورية أكاديمية
أعرض في EDS

Effects of the GABA(B) agonist baclofen on volitional swallowing in normal subjects

التفاصيل البيبلوغرافية
العنوان: Effects of the GABA(B) agonist baclofen on volitional swallowing in normal subjects
المؤلفون: Jui‐Sheng Hung, Shu‐Wei Liang, Taher Omari, Ming‐Wun Wong, Wei‐Yi Lei, Chih‐Hsun Yi, Tso‐Tsai Liu, Lin Lin, Chien‐Lin Chen
المصدر: Kaohsiung Journal of Medical Sciences, Vol 39, Iss 1, Pp 80-86 (2023)
بيانات النشر: Wiley, 2023.
سنة النشر: 2023
المجموعة: LCC:Medicine (General)
مصطلحات موضوعية: baclofen, deglutition, electric impedance, manometry, pharynx, Medicine (General), R5-920
الوصف: Abstract The GABA(B) receptor agonist baclofen is known to suppress the rate of spontaneous swallowing but not pharyngeal muscle contraction. The extent to which baclofen may alter volitional swallowing is not currently known. We investigated the effects of baclofen in healthy subjects, hypothesizing that baclofen exposure would alter volume‐regulation and/or piecemeal deglutition behaviors during volitional swallowing attempts. Pharyngeal high‐resolution manometry impedance (P‐HRM‐I) protocol was used to assess swallowing function of 22 healthy adult volunteers (median 29 years) who were investigated on two occasions, receiving 40 mg baclofen (oral) 1 h before study, or placebo (randomized). Standard swallow function variables recommended by the pharyngeal HRM Working Group were derived for 5 ml, 10 ml, and 20 ml volumes of thin and extremely thick liquid challenges. Multiple swallow behaviors, comprising two swallows
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2410-8650
1607-551X
Relation: https://doaj.org/toc/1607-551X; https://doaj.org/toc/2410-8650
DOI: 10.1002/kjm2.12607
URL الوصول: https://doaj.org/article/1614acdc425d41bb8d73f22100b1c209
رقم الأكسشن: edsdoj.1614acdc425d41bb8d73f22100b1c209
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:24108650
1607551X
DOI:10.1002/kjm2.12607