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Interferon Alpha on Expression of hTERT mRNA in Peripheral Blood Mononuclear Cells of Patients with Chronic Hepatitis B

التفاصيل البيبلوغرافية
العنوان: Interferon Alpha on Expression of hTERT mRNA in Peripheral Blood Mononuclear Cells of Patients with Chronic Hepatitis B
المؤلفون: Chuan-wu Zhu, Ming Chen, Xiang-rong Luo, Hai-yan Wang, Li-hua Wang, Jian-hong Wu, Ming Li, Xue-hua Zhang, Wei Zhu, Jian-zhong Ye, Feng Qian
المصدر: Clinical and Developmental Immunology, Vol 2011 (2011)
بيانات النشر: Wiley, 2011.
سنة النشر: 2011
المجموعة: LCC:Immunologic diseases. Allergy
مصطلحات موضوعية: Immunologic diseases. Allergy, RC581-607
الوصف: Cell division is closely related to telomerase activity (hTERT mRNA). Lower expression of lymphocitic hTERT mRNA may easily cause cell aging, which is not beneficial to maintaining a durable lymphocyte division. To date, there is no study to investigate IFNα therapy on hTERT mRNA expression in PBMCs of patients with chronic hepatitis B (CHB). We quantitatively detected hTERT mRNA from study subjects and made each hTERT mRNA normalized (NhTERT mRNA). Mean NhTERT mRNA level was lower in either CHB group, but it significantly increased in IFNα-treated group compared with CHB control group, and a longer duration of IFNα therapy could increase the level. Moreover, the mean NhTERT mRNA in subgroup with HBeAg loss was significantly higher than that in subgroup without. NhTERT mRNA was markedly correlated with CD3+ T lymphocyte count and CD4+/CD8+ ratio. The results showed that IFNα therapy could upregulate the expression of hTERT mRNA in PBMCs.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1740-2522
1740-2530
Relation: https://doaj.org/toc/1740-2522; https://doaj.org/toc/1740-2530
DOI: 10.1155/2011/920146
URL الوصول: https://doaj.org/article/e16eacc1cee44853afee9b8ceddfd795
رقم الأكسشن: edsdoj.16eacc1cee44853afee9b8ceddfd795
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17402522
17402530
DOI:10.1155/2011/920146