دورية أكاديمية
The relationships between subclinical OCD symptoms, beta/gamma-band power, and the rate of evidence integration during perceptual decision making
| العنوان: | The relationships between subclinical OCD symptoms, beta/gamma-band power, and the rate of evidence integration during perceptual decision making |
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| المؤلفون: | Alec Solway, Isabella Schneider, Yuqing Lei |
| المصدر: | NeuroImage: Clinical, Vol 34, Iss , Pp 102975- (2022) |
| بيانات النشر: | Elsevier, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Computer applications to medicine. Medical informatics LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: | Beta, Gamma, Decision making, Obsessive-compulsive disorder, Computational modeling, Drift-diffusion model, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Previous studies have demonstrated that the rate of evidence integration during perceptual decision making, a specific computationally defined parameter, is negatively correlated with both subclinical symptoms of OCD measured on a continuum and categorically diagnosed patient status. However, the neural mechanisms underlying this deficit are unknown. Separate work has shown that both gamma and beta-band power are related to evidence integration, and differences in beta-band power in particular have been hypothesized to hinder flexible behavioral control. We sought to unify these two disparate literatures, one on OCD-related information processing differences constrained by behavioral data alone, and the other on the neural correlates of evidence integration. Using computational modeling and scalp EEG, we tested (N = 67) the relationships between subclinical symptom scores, drift rate, and gamma/beta-band activity during perceptual decision making. We replicated both prior work showing deficits in evidence integration as a function of OCD symptoms, and work showing a relationship between evidence integration and gamma and beta-band power. As predicted, the slope of beta-band power was correlated with OCD symptoms. However, the relationships between OCD symptoms and drift rate and the slopes of gamma and beta-band power and drift rate remained unchanged when simultaneously accounting for all variables, speaking against the hypothesis that differences in band-band power explain drift rate deficits. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2213-1582 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2213158222000407; https://doaj.org/toc/2213-1582 |
| DOI: | 10.1016/j.nicl.2022.102975 |
| URL الوصول: | https://doaj.org/article/a17296a78f1840f1be0999312584d38f |
| رقم الأكسشن: | edsdoj.17296a78f1840f1be0999312584d38f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 22131582 |
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| DOI: | 10.1016/j.nicl.2022.102975 |