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Mathematical Modelling of the Effects of Plasma Treatment on the Diffusivity of Biofilm

التفاصيل البيبلوغرافية
العنوان: Mathematical Modelling of the Effects of Plasma Treatment on the Diffusivity of Biofilm
المؤلفون: Tripti Thapa Gupta, Surya B. Karki, Ronald Fournier, Halim Ayan
المصدر: Applied Sciences, Vol 8, Iss 10, p 1729 (2018)
بيانات النشر: MDPI AG, 2018.
سنة النشر: 2018
المجموعة: LCC:Technology
LCC:Engineering (General). Civil engineering (General)
LCC:Biology (General)
LCC:Physics
LCC:Chemistry
مصطلحات موضوعية: biofilm, Pseudomonas aeruginosa, non-thermal plasma, CHX, diffusion, mathematical modelling, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999
الوصف: Biofilm formation on implanted medical devices is the reason for most of the nosocomial infections in clinical settings. Biofilms are more resistant to antimicrobials than their planktonic cells mainly because of the presence of the matrix of extracellular polymeric substances (EPSs), which acts as a physical barrier that limits the transport of antimicrobials inside the biofilm. A combinatorial antimicrobial approach of a non-thermal plasma and chlorhexidine (CHX) digluconate can be used to sterilize those surfaces contaminated with biofilm. However, the reason behind achieving this combinatorial decontamination is not known. Thus, in this study, we developed a mathematical model to explain the reason behind sterilization with the combinatorial treatment approach. It was found that the application of plasma prior to treatment with CHX is disrupting the biofilm and making it very porous. This is allowing CHX to penetrate deeper inside the porous biofilm, which is then effective at sterilizing the biofilm.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2076-3417
Relation: http://www.mdpi.com/2076-3417/8/10/1729; https://doaj.org/toc/2076-3417
DOI: 10.3390/app8101729
URL الوصول: https://doaj.org/article/18d6cddc8b6c4b17b3d314b7f2329cbb
رقم الأكسشن: edsdoj.18d6cddc8b6c4b17b3d314b7f2329cbb
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20763417
DOI:10.3390/app8101729