دورية أكاديمية
Expression of pattern recognition receptors in liver biopsy specimens of children chronically infected with HBV and HCV
| العنوان: | Expression of pattern recognition receptors in liver biopsy specimens of children chronically infected with HBV and HCV |
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| المؤلفون: | Wojciech Służewski, Jan Sikora, Elżbieta Kaczmarek, Husam Samara, Renata Jenek, Anna Mania, Arleta Kowala-Piaskowska, Iwona Mozer-Lisewska, Jan Żeromski |
| المصدر: | Folia Histochemica et Cytobiologica, Vol 49, Iss 3, Pp 410-416 (2011) |
| بيانات النشر: | Via Medica, 2011. |
| سنة النشر: | 2011 |
| المجموعة: | LCC:Cytology |
| مصطلحات موضوعية: | pattern recognition receptors, viral hepatitis, liver biopsy, children, immunohistochemistry, Cytology, QH573-671 |
| الوصف: | Pattern recognition receptors (PRRs) constitute a pivotal arm of innate immunity. Their distribution is widespread and not limited to cells of the immune system. Following our previous findings concerning the expression of Toll-like receptors (TLRs) 2, 3 and 4 in chronic viral hepatitis C of children, we wished to search for other PRRs, including other TLRs, NOD-like receptors (NLRs) and RIG-1-like helicase receptors (RLR) in infected hepatocytes. Liver biopsy fragments from ten children with chronic hepatitis B and C were used and two others in which hepatotropic virus infection was excluded. Frozen sections of liver samples were subjected to ABC immunohistochemistry (IHC) following incubation with a set of antibodies. Results of IHC findings were screened for correlation with clinical/laboratory data of patients. It was found that several PRRs could be shown in affected hepatocytes, but the incidence was higher in hepatitis C than in B. In hepatitis C, TLR1, 2, 4, NALP and RIG-1 helicase showed the most marked expression. In hepatitis B, TLR1, 3, 9, NOD1 and NALP expression were the most conspicuous. Expression PRRs in liver from hepatitis of unknown origin was much lower. It was also the case in cytospins from human hepatoma cell line. Several correlations between PRRs expression and clinical findings in patients could be shown by statistical exploration. In conclusion, this data suggests some role for PRRs in the pathogenesis of chronic viral hepatitis. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 3, pp. 410–416) |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0239-8508 1897-5631 |
| Relation: | http://czasopisma.viamedica.pl/fhc/article/view/9434; https://doaj.org/toc/0239-8508; https://doaj.org/toc/1897-5631 |
| DOI: | 10.5603/9434 |
| URL الوصول: | https://doaj.org/article/de1935ea1d044e76ac0d878f26509e39 |
| رقم الأكسشن: | edsdoj.1935ea1d044e76ac0d878f26509e39 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 02398508 18975631 |
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| DOI: | 10.5603/9434 |