دورية أكاديمية
The Development of Super-Saturated Rebamipide Eye Drops for Enhanced Solubility, Stability, Patient Compliance, and Bioavailability
العنوان: | The Development of Super-Saturated Rebamipide Eye Drops for Enhanced Solubility, Stability, Patient Compliance, and Bioavailability |
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المؤلفون: | Dong-Jin Jang, Jun Hak Lee, Da Hun Kim, Jin-Woo Kim, Tae-Sung Koo, Kwan Hyung Cho |
المصدر: | Pharmaceutics, Vol 15, Iss 3, p 950 (2023) |
بيانات النشر: | MDPI AG, 2023. |
سنة النشر: | 2023 |
المجموعة: | LCC:Pharmacy and materia medica |
مصطلحات موضوعية: | rebamipide, super-saturated eye drop, physical stability, ophthalmic bioavailability, Pharmacy and materia medica, RS1-441 |
الوصف: | The present study aimed to develop clear aqueous rebamipide (REB) eye drops to enhance solubility, stability, patient compliance, and bioavailability. For the preparation of a super-saturated 1.5% REB solution, the pH-modification method using NaOH and a hydrophilic polymer was employed. Low-viscosity hydroxypropyl methylcellulose (HPMC 4.5cp) was selected and worked efficiently to suppress REB precipitation at 40 °C for 16 days. The additionally optimized eye drops formulation (F18 and F19) using aminocaproic acid and D-sorbitol as a buffering agent and an osmotic agent, respectively, demonstrated long-term physicochemical stability at 25 °C and 40 °C for 6 months. The hypotonicity (max and 2.60- and 3.64-times higher exposure in the cornea and aqueous humor). In conclusion, the formulations suggested in the present study are promising candidates and offer enhanced solubility, stability, patient compliance, and bioavailability. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1999-4923 |
Relation: | https://www.mdpi.com/1999-4923/15/3/950; https://doaj.org/toc/1999-4923 |
DOI: | 10.3390/pharmaceutics15030950 |
URL الوصول: | https://doaj.org/article/19ccce13c09a403cada5c6402bfb58e1 |
رقم الأكسشن: | edsdoj.19ccce13c09a403cada5c6402bfb58e1 |
قاعدة البيانات: | Directory of Open Access Journals |
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