دورية أكاديمية
Epigallocatechin Gallate (EGCG), a Green Tea Polyphenol, Reduces Coronavirus Replication in a Mouse Model
| العنوان: | Epigallocatechin Gallate (EGCG), a Green Tea Polyphenol, Reduces Coronavirus Replication in a Mouse Model |
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| المؤلفون: | Rackhyun Park, Minsu Jang, Yea-In Park, Yeonjeong Park, Woochul Jung, Jayhyun Park, Junsoo Park |
| المصدر: | Viruses, Vol 13, Iss 12, p 2533 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Microbiology |
| مصطلحات موضوعية: | coronavirus, green tea, EGCG, HCoV-OC43, Microbiology, QR1-502 |
| الوصف: | The COVID-19 pandemic has resulted in a huge number of deaths from 2020 to 2021; however, effective antiviral drugs against SARS-CoV-2 are currently under development. Recent studies have demonstrated that green tea polyphenols, particularly EGCG, inhibit coronavirus enzymes as well as coronavirus replication in vitro. Herein, we examined the inhibitory effect of green tea polyphenols on coronavirus replication in a mouse model. We used epigallocatechin gallate (EGCG) and green tea polyphenols containing more than 60% catechin (GTP60) and human coronavirus OC43 (HCoV-OC43) as a surrogate for SARS-CoV-2. Scanning electron microscopy analysis results showed that HCoV-OC43 infection resulted in virion particle production in infected cells. EGCG and GTP60 treatment reduced coronavirus protein and virus production in the cells. Finally, EGCG- and GTP60-fed mice exhibited reduced levels of coronavirus RNA in mouse lungs. These results demonstrate that green tea polyphenol treatment is effective in decreasing the level of coronavirus in vivo. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 13122533 1999-4915 |
| Relation: | https://www.mdpi.com/1999-4915/13/12/2533; https://doaj.org/toc/1999-4915 |
| DOI: | 10.3390/v13122533 |
| URL الوصول: | https://doaj.org/article/19e3abd6a1f8449e905410e4f9598f99 |
| رقم الأكسشن: | edsdoj.19e3abd6a1f8449e905410e4f9598f99 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13122533 19994915 |
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| DOI: | 10.3390/v13122533 |