دورية أكاديمية

Role of Neoadjuvant Chemotherapy in High-Grade Neuroendocrine Carcinoma of the Uterine Cervix

التفاصيل البيبلوغرافية
العنوان: Role of Neoadjuvant Chemotherapy in High-Grade Neuroendocrine Carcinoma of the Uterine Cervix
المؤلفون: Hyerim Eum, Yoon-Kyung Shin, Ju-Hyun Kim, Yong Man Kim, Jong-Hyeok Kim, Dae-Shik Suh, Dae-Yeon Kim, Jeong-Yeol Park
المصدر: Clinical and Experimental Obstetrics & Gynecology, Vol 51, Iss 7, p 170 (2024)
بيانات النشر: IMR Press, 2024.
سنة النشر: 2024
المجموعة: LCC:Gynecology and obstetrics
مصطلحات موضوعية: uterine cervical neoplasm, neuroendocrine carcinoma, prognosis, neoadjuvant chemotherapy, Gynecology and obstetrics, RG1-991
الوصف: Background: This study aimed to assess the feasibility and efficacy of neoadjuvant chemotherapy (NACT) in treating patients with high-grade neuroendocrine carcinoma of the uterine cervix (HGNEC). Methods: We performed a retrospective case-control study at Asan Medical Center, Seoul, Republic of Korea, from January 1993 to December 2017, involving 60 patients with surgically treated HGNEC. Thirteen patients (21.7%) received NACT before undergoing surgery. Regarding the comparison between the group that underwent NACT and the group that did not, we used a propensity score-matched analysis, matching 22 patients in the primary radical surgery group with 11 patients in the neoadjuvant chemotherapy followed by radical hysterectomy group. Results: In the entire cohort, primary open surgery was more common in the primary surgery group compared to the NACT group (p = 0.004). After propensity score matching (PSM), the median tumor size was 3.5 cm in the primary surgery group and 2.4 cm in the NACT group (p = 0.078). After matching, there was no significant difference in the recurrence rate between the two groups (63.6% in the primary surgery group vs. 63.6% in the neoadjuvant chemotherapy group, p = 0.782). After PSM, the primary surgery group exhibited a lower intraoperative transfusion rate (10%) than the NACT group (45.5%, p = 0.052). Conclusions: While NACT was feasible in patients with HGNEC, it did not significantly improve the survival rate over primary radical surgery.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 0390-6663
Relation: https://www.imrpress.com/journal/CEOG/51/7/10.31083/j.ceog5107170; https://doaj.org/toc/0390-6663
DOI: 10.31083/j.ceog5107170
URL الوصول: https://doaj.org/article/1a03ff97cb464a4799fd43449459b639
رقم الأكسشن: edsdoj.1a03ff97cb464a4799fd43449459b639
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:03906663
DOI:10.31083/j.ceog5107170