دورية أكاديمية
Gerontoxanthone I and Macluraxanthone Induce Mitophagy and Attenuate Ischemia/Reperfusion Injury
| العنوان: | Gerontoxanthone I and Macluraxanthone Induce Mitophagy and Attenuate Ischemia/Reperfusion Injury |
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| المؤلفون: | Qian Xiang, Man Wu, Li Zhang, Wenwei Fu, Jinling Yang, Baojun Zhang, Zhaoqing Zheng, Hong Zhang, Yuanzhi Lao, Hongxi Xu |
| المصدر: | Frontiers in Pharmacology, Vol 11 (2020) |
| بيانات النشر: | Frontiers Media S.A., 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | mitophagy, PINK1-Parkin pathway, Gerontoxanthone I, Macluraxanthone, ischemia/reperfusion injury, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | Mitophagy is a crucial process in controlling mitochondrial biogenesis. Balancing mitophagy and mitochondrial functions is required for maintaining cellular homeostasis. In this study, we found that Gerontoxanthone I (GeX1) and Macluraxanthone (McX), xanthone derivatives isolated from Garcinia bracteata C. Y. Wu ex Y. H. Li, induced Parkin puncta accumulation and promoted mitophagy. GeX1 and McX treatment induced the degradation of mitophagy-related proteins such as Tom20 and Tim23. GeX1 and McX directly stabilized PTEN-induced putative kinase 1 (PINK1) on the outer membrane of the mitochondria, and then recruited Parkin to mitochondria. This significantly induced phosphorylation and ubiquitination of Parkin, suggesting that GeX1 and McX mediate mitophagy through the PINK1-Parkin pathway. Transfecting ParkinS65A or pretreated MG132 abolished the induction effects of GeX1 and McX on mitophagy. Furthermore, GeX1 and McX treatment decreased cell death and the level of ROS in an ischemia/reperfusion (IR) injury model in H9c2 cells compared to a control group. Taken together, our data suggested that GeX1 and McX induce PINK1-Parkin–mediated mitophagy and attenuate myocardial IR injury in vitro. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1663-9812 13127659 |
| Relation: | https://www.frontiersin.org/article/10.3389/fphar.2020.00452/full; https://doaj.org/toc/1663-9812 |
| DOI: | 10.3389/fphar.2020.00452 |
| URL الوصول: | https://doaj.org/article/ec1a4e6e4b3246a989d53dd131276595 |
| رقم الأكسشن: | edsdoj.1a4e6e4b3246a989d53dd131276595 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16639812 13127659 |
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| DOI: | 10.3389/fphar.2020.00452 |