دورية أكاديمية
Diagnostic accuracy of a set of clinical and radiological criteria for screening of COVID-19 using RT-PCR as the reference standard
العنوان: | Diagnostic accuracy of a set of clinical and radiological criteria for screening of COVID-19 using RT-PCR as the reference standard |
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المؤلفون: | Mirella Cristine Oliveira, Karoleen Oswald Scharan, Bruna Isadora Thomés, Rafaella Stradiotto Bernardelli, Fernanda Baeumle Reese, Amanda Christina Kozesinski-Nakatani, Cintia Cristina Martins, Suzana Margareth Ajeje Lobo, Álvaro Réa-Neto |
المصدر: | BMC Pulmonary Medicine, Vol 23, Iss 1, Pp 1-9 (2023) |
بيانات النشر: | BMC, 2023. |
سنة النشر: | 2023 |
المجموعة: | LCC:Diseases of the respiratory system |
مصطلحات موضوعية: | COVID-19 testing, Intensive care units, Tomography, Sensitivity and specificity, Mass screening, Diseases of the respiratory system, RC705-779 |
الوصف: | Abstract Background The gold-standard method for establishing a microbiological diagnosis of COVID-19 is reverse-transcriptase polymerase chain reaction (RT-PCR). This study aimed to evaluate the accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of a set of clinical-radiological criteria for COVID-19 screening in patients with severe acute respiratory failure (SARF) admitted to intensive care units (ICUs), using reverse-transcriptase polymerase chain reaction (RT-PCR) as the reference standard. Methods Diagnostic accuracy study including a historical cohort of 1009 patients consecutively admitted to ICUs across six hospitals in Curitiba (Brazil) from March to September, 2020. The sample was stratified into groups by the strength of suspicion for COVID-19 (strong versus weak) using parameters based on three clinical and radiological (chest computed tomography) criteria. The diagnosis of COVID-19 was confirmed by RT-PCR (referent). Results With respect to RT-PCR, the proposed criteria had 98.5% (95% confidence interval [95% CI] 97.5–99.5%) sensitivity, 70% (95% CI 65.8–74.2%) specificity, 85.5% (95% CI 83.4–87.7%) accuracy, PPV of 79.7% (95% CI 76.6–82.7%) and NPV of 97.6% (95% CI 95.9–99.2%). Similar performance was observed when evaluated in the subgroups of patients admitted with mild/moderate respiratory disfunction, and severe respiratory disfunction. Conclusion The proposed set of clinical-radiological criteria were accurate in identifying patients with strong versus weak suspicion for COVID-19 and had high sensitivity and considerable specificity with respect to RT-PCR. These criteria may be useful for screening COVID-19 in patients presenting with SARF. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1471-2466 |
Relation: | https://doaj.org/toc/1471-2466 |
DOI: | 10.1186/s12890-023-02369-9 |
URL الوصول: | https://doaj.org/article/1b85b916c5624140912577d34fac40c9 |
رقم الأكسشن: | edsdoj.1b85b916c5624140912577d34fac40c9 |
قاعدة البيانات: | Directory of Open Access Journals |
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