دورية أكاديمية
The Effects of Prenatal Norharman Exposure on Seizure Severity in Rats
| العنوان: | The Effects of Prenatal Norharman Exposure on Seizure Severity in Rats |
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| المؤلفون: | Mohammad Hossein Esmaeili, Mohammad Sofiabadi, Amin Afshar |
| المصدر: | The Journal of Qazvin University of Medical Sciences, Vol 25, Iss 1, Pp 19-24 (2021) |
| بيانات النشر: | Qazvin University of Medical Sciences & Health Services, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | norharman, seizure, pentylenetetrazol, rat, Medicine |
| الوصف: | Background: Norhraman is an alkaloid that can damage the nervous system. Objective: This experimental study aimed to investigate the effects of prenatal norharman exposure on seizure severity in adult rats. Methods: A total of 36 Wistar rats were randomly divided into 3 groups as follows: Control, sham (solvent), and norharman (1000 ug/kg). The sham and norharman groups were treated once daily for 8-18 of the fetal period. 2 months after birth, kindling was performed by the daily injection of Pentylenetetrazol (PTZ) (30 mg/kg); then, the seizure behavior was recorded for approximately 30 minutes. The obtained data were analyzed using Analysis of Variance (ANOVA) and Tukey’s posthoc test. Results: The present study data indicated that administrating norharman in the fetal period increased seizure responses to PTZ, i.e., significant in the examined female rats (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Persian |
| تدمد: | 1561-3666 2228-7213 |
| Relation: | https://journal.qums.ac.ir/article-1-3149-en.html; https://doaj.org/toc/1561-3666; https://doaj.org/toc/2228-7213 |
| DOI: | 10.32598/JQUMS.25.1.3 |
| URL الوصول: | https://doaj.org/article/1d053933d3d04bb59c7036b56a2e2ef3 |
| رقم الأكسشن: | edsdoj.1d053933d3d04bb59c7036b56a2e2ef3 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15613666 22287213 |
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| DOI: | 10.32598/JQUMS.25.1.3 |