دورية أكاديمية
Luteolin Reduces Alzheimer’s Disease Pathologies Induced by Traumatic Brain Injury
| العنوان: | Luteolin Reduces Alzheimer’s Disease Pathologies Induced by Traumatic Brain Injury |
|---|---|
| المؤلفون: | Darrell Sawmiller, Song Li, Md Shahaduzzaman, Adam J. Smith, Demian Obregon, Brian Giunta, Cesar V. Borlongan, Paul R. Sanberg, Jun Tan |
| المصدر: | International Journal of Molecular Sciences, Vol 15, Iss 1, Pp 895-904 (2014) |
| بيانات النشر: | MDPI AG, 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | traumatic brain injury, Alzheimer’s disease, amyloidogenesis, tauopathy, GSK, neuroinflammation, luteolin, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Traumatic brain injury (TBI) occurs in response to an acute insult to the head and is recognized as a major risk factor for Alzheimer’s disease (AD). Indeed, recent studies have suggested a pathological overlap between TBI and AD, with both conditions exhibiting amyloid-beta (Aβ) deposits, tauopathy, and neuroinflammation. Additional studies involving animal models of AD indicate that some AD-related genotypic determinants may be critical factors enhancing temporal and phenotypic symptoms of TBI. Thus in the present study, we examined sub-acute effects of moderate TBI delivered by a gas-driven shock tube device in Aβ depositing Tg2576 mice. Three days later, significant increases in b-amyloid deposition, glycogen synthase-3 (GSK-3) activation, phospho-tau, and pro-inflammatory cytokines were observed. Importantly, peripheral treatment with the naturally occurring flavonoid, luteolin, significantly abolished these accelerated pathologies. This study lays the groundwork for a safe and natural compound that could prevent or treat TBI with minimal or no deleterious side effects in combat personnel and others at risk or who have experienced TBI. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 |
| Relation: | http://www.mdpi.com/1422-0067/15/1/895; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms15010895 |
| URL الوصول: | https://doaj.org/article/1da77728ba52494d90c0641cddb61acf |
| رقم الأكسشن: | edsdoj.1da77728ba52494d90c0641cddb61acf |
| قاعدة البيانات: | Directory of Open Access Journals |
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