دورية أكاديمية
Advances in stem cell therapy for peritoneal fibrosis: from mechanisms to therapeutics
| العنوان: | Advances in stem cell therapy for peritoneal fibrosis: from mechanisms to therapeutics |
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| المؤلفون: | Weiyan Huang, Demeng Xia, Wendi Bi, Xueli Lai, Bing Yu, Wei Chen |
| المصدر: | Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-15 (2023) |
| بيانات النشر: | BMC, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine (General) LCC:Biochemistry |
| مصطلحات موضوعية: | Stem cell, Peritoneal fibrosis, Mesothelial–mesenchymal transition, Mechanism, Cell therapy, Medicine (General), R5-920, Biochemistry, QD415-436 |
| الوصف: | Abstract Peritoneal fibrosis (PF) is a pathophysiological condition caused by a variety of pathogenic factors. The most important features of PF are mesothelial–mesenchymal transition and accumulation of activated (myo-)fibroblasts, which hinder effective treatment; thus, it is critical to identify other practical approaches. Recently, stem cell (SC) therapy has been indicated to be a potential strategy for this disease. Increasing evidence suggests that many kinds of SCs alleviate PF mainly by differentiating into mesothelial cells; secreting cytokines and extracellular vesicles; or modulating immune cells, particularly macrophages. However, there are relatively few articles summarizing research in this direction. In this review, we summarize the risk factors for PF and discuss the therapeutic roles of SCs from different sources. In addition, we outline effective approaches and potential mechanisms of SC therapy for PF. We hope that our review of articles in this area will provide further inspiration for research on the use of SCs in PF treatment. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1757-6512 |
| Relation: | https://doaj.org/toc/1757-6512 |
| DOI: | 10.1186/s13287-023-03520-3 |
| URL الوصول: | https://doaj.org/article/1e8d7e9bfc4b4307a73f6f1534145599 |
| رقم الأكسشن: | edsdoj.1e8d7e9bfc4b4307a73f6f1534145599 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 17576512 |
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| DOI: | 10.1186/s13287-023-03520-3 |