دورية أكاديمية
Myelodysplastic syndrome: validation of flow cytometry multilineage score system
| العنوان: | Myelodysplastic syndrome: validation of flow cytometry multilineage score system |
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| المؤلفون: | Helena Varela de Araújo, Rodolfo Patussi Correia, Laiz Cameirão Bento, Andressa da Costa Vaz, Flávia Arandas de Sousa, Anderson Marega Alexandre, Daniela Schimidell, Eduardo de Carvalho Pedro, Márcia Regina Ioshida, Rodrigo de Souza Barroso, Nydia Strachman Bacal |
| المصدر: | Einstein (São Paulo), Vol 18 (2020) |
| بيانات النشر: | Instituto Israelita de Ensino e Pesquisa Albert Einstein, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Myelodysplastic syndromes, Flow cytometry, Cytomorphology, Histology, Cytogenetics, Multilineage score system, Medicine |
| الوصف: | ABSTRACT Objective To validate multilineage score system correlating results of flow cytometry, cytogenetics, cytomorphology and histology from samples of patients with suspected myelodysplastic syndrome or cytopenia of unknown origin. Methods A retrospective study analyzing laboratory data of 49 patients with suspected myelodysplastic syndrome or cytopenia of unknown origin, carried out between May and September 2017. The inclusion criteria were availability of flow cytometry results, and at least one more method, such as morphology, histology or cytogenetics. Thirty-eight patients were classified as diagnosis of myelodysplastic syndromes, whereas 11 were classified as normal. Patients were evaluated based on score systems, Ogata score and flow cytometry multilineage score. Results Comparing the scores obtained in the Ogata score and the multilineage score, it was observed that in four cases the Ogata score was zero or 1 point, while the multilineage score was higher than 3 points. In addition, in 12 cases with Ogata score of 2, the multilineage score was greater than 3. Conclusion The flow cytometry multilineage score system demonstrated to be more effective in dysplasia analysis, by assessing the erythroid, monocytic, granulocytic and precursor cell lineages, apart from the parameters evaluated by the Ogata score. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Portuguese |
| تدمد: | 2317-6385 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082020000100232&tlng=en; http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082020000100232&tlng=pt; https://doaj.org/toc/2317-6385 |
| DOI: | 10.31744/einstein_journal/2020ao4966 |
| URL الوصول: | https://doaj.org/article/1eac86b9fe9a44a8ae46fe94a202b587 |
| رقم الأكسشن: | edsdoj.1eac86b9fe9a44a8ae46fe94a202b587 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23176385 |
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| DOI: | 10.31744/einstein_journal/2020ao4966 |