دورية أكاديمية
Dysgerminoma with Estrogen-Producing Functioning Stroma Presenting Precocious Puberty
| العنوان: | Dysgerminoma with Estrogen-Producing Functioning Stroma Presenting Precocious Puberty |
|---|---|
| المؤلفون: | Shunsuke Nagase, Kanako Ogura, Karin Ashizawa, Nana Nakazawa-Tanaka, Masahiko Urao, Masaharu Fukunaga, Yuto Yamazaki, Hironobu Sasano, Toshiharu Matsumoto |
| المصدر: | Case Reports in Pathology, Vol 2021 (2021) |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Pathology |
| مصطلحات موضوعية: | Pathology, RB1-214 |
| الوصف: | Dysgerminoma is a malignant ovarian germ cell tumor, and unlike sex-cord stromal tumors, endocrine manifestation is considered rare. Here, we report the first case of dysgerminoma presenting precocious puberty. The patient is a 7-year-old girl who presented with a breast development in Tanner stage 3. Serum estradiol (E2) was markedly elevated while luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were suppressed below the detection limit. Microscopically, the right ovarian mass displayed nests of large polygonal cells and fibrous septa which were focally concentrated by theca-like plump spindle cells. Immunohistochemistry revealed that the spindle cells expressed various steroidogenic enzymes involved in estrogen biosynthesis including P450 aromatase. The tumor was diagnosed with pure dysgerminoma with estrogen-producing functioning stroma. After the operation, serum E2 declined below the detection limit; LH and FSH returned within the normal range. This case demonstrates that even a conventional dysgerminoma can present endocrine manifestation through functioning stroma. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2090-6781 2090-679X |
| Relation: | https://doaj.org/toc/2090-6781; https://doaj.org/toc/2090-679X |
| DOI: | 10.1155/2021/5545645 |
| URL الوصول: | https://doaj.org/article/1f3059fde9084e2ea1ff02b291a84577 |
| رقم الأكسشن: | edsdoj.1f3059fde9084e2ea1ff02b291a84577 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20906781 2090679X |
|---|---|
| DOI: | 10.1155/2021/5545645 |