دورية أكاديمية
Dysgerminoma with Estrogen-Producing Functioning Stroma Presenting Precocious Puberty
العنوان: | Dysgerminoma with Estrogen-Producing Functioning Stroma Presenting Precocious Puberty |
---|---|
المؤلفون: | Shunsuke Nagase, Kanako Ogura, Karin Ashizawa, Nana Nakazawa-Tanaka, Masahiko Urao, Masaharu Fukunaga, Yuto Yamazaki, Hironobu Sasano, Toshiharu Matsumoto |
المصدر: | Case Reports in Pathology, Vol 2021 (2021) |
بيانات النشر: | Wiley, 2021. |
سنة النشر: | 2021 |
المجموعة: | LCC:Pathology |
مصطلحات موضوعية: | Pathology, RB1-214 |
الوصف: | Dysgerminoma is a malignant ovarian germ cell tumor, and unlike sex-cord stromal tumors, endocrine manifestation is considered rare. Here, we report the first case of dysgerminoma presenting precocious puberty. The patient is a 7-year-old girl who presented with a breast development in Tanner stage 3. Serum estradiol (E2) was markedly elevated while luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were suppressed below the detection limit. Microscopically, the right ovarian mass displayed nests of large polygonal cells and fibrous septa which were focally concentrated by theca-like plump spindle cells. Immunohistochemistry revealed that the spindle cells expressed various steroidogenic enzymes involved in estrogen biosynthesis including P450 aromatase. The tumor was diagnosed with pure dysgerminoma with estrogen-producing functioning stroma. After the operation, serum E2 declined below the detection limit; LH and FSH returned within the normal range. This case demonstrates that even a conventional dysgerminoma can present endocrine manifestation through functioning stroma. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2090-6781 2090-679X |
Relation: | https://doaj.org/toc/2090-6781; https://doaj.org/toc/2090-679X |
DOI: | 10.1155/2021/5545645 |
URL الوصول: | https://doaj.org/article/1f3059fde9084e2ea1ff02b291a84577 |
رقم الأكسشن: | edsdoj.1f3059fde9084e2ea1ff02b291a84577 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 20906781 2090679X |
---|---|
DOI: | 10.1155/2021/5545645 |