دورية أكاديمية
Tumor cytotoxicity and immunogenicity of a novel V-jet neon plasma source compared to the kINPen
العنوان: | Tumor cytotoxicity and immunogenicity of a novel V-jet neon plasma source compared to the kINPen |
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المؤلفون: | Lea Miebach, Eric Freund, Stefan Horn, Felix Niessner, Sanjeev Kumar Sagwal, Thomas von Woedtke, Steffen Emmert, Klaus-Dieter Weltmann, Ramona Clemen, Anke Schmidt, Torsten Gerling, Sander Bekeschus |
المصدر: | Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021) |
بيانات النشر: | Nature Portfolio, 2021. |
سنة النشر: | 2021 |
المجموعة: | LCC:Medicine LCC:Science |
مصطلحات موضوعية: | Medicine, Science |
الوصف: | Abstract Recent research indicated the potential of cold physical plasma in cancer therapy. The plethora of plasma-derived reactive oxygen and nitrogen species (ROS/RNS) mediate diverse antitumor effects after eliciting oxidative stress in cancer cells. We aimed at exploiting this principle using a newly designed dual-jet neon plasma source (Vjet) to treat colorectal cancer cells. A treatment time-dependent ROS/RNS generation induced oxidation, growth retardation, and cell death within 3D tumor spheroids were found. In TUM-CAM, a semi in vivo model, the Vjet markedly reduced vascularized tumors' growth, but an increase of tumor cell immunogenicity or uptake by dendritic cells was not observed. By comparison, the argon-driven single jet kINPen, known to mediate anticancer effects in vitro, in vivo, and in patients, generated less ROS/RNS and terminal cell death in spheroids. In the TUM-CAM model, however, the kINPen was equivalently effective and induced a stronger expression of immunogenic cancer cell death (ICD) markers, leading to increased phagocytosis of kINPen but not Vjet plasma-treated tumor cells by dendritic cells. Moreover, the Vjet was characterized according to the requirements of the DIN-SPEC 91315. Our results highlight the plasma device-specific action on cancer cells for evaluating optimal discharges for plasma cancer treatment. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2045-2322 |
Relation: | https://doaj.org/toc/2045-2322 |
DOI: | 10.1038/s41598-020-80512-w |
URL الوصول: | https://doaj.org/article/d1f4e475416d406499aee390b8c8b4e6 |
رقم الأكسشن: | edsdoj.1f4e475416d406499aee390b8c8b4e6 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 20452322 |
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DOI: | 10.1038/s41598-020-80512-w |