دورية أكاديمية
The prognostic implications and tumor-promoting functions of CHSY3 in gastric cancer
العنوان: | The prognostic implications and tumor-promoting functions of CHSY3 in gastric cancer |
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المؤلفون: | Han Wang, Junchang Zhang, Zhuoqi Wei, Songyao Chen, Jiabin Zheng, Yong Li |
المصدر: | Frontiers in Immunology, Vol 15 (2024) |
بيانات النشر: | Frontiers Media S.A., 2024. |
سنة النشر: | 2024 |
المجموعة: | LCC:Immunologic diseases. Allergy |
مصطلحات موضوعية: | gastric cancer, CHSY3, tumor-associated macrophages, prognosis, tumor immune microenvironment, Immunologic diseases. Allergy, RC581-607 |
الوصف: | Chondroitin sulfate synthase 3 (CHSY3) is an important enzyme that regulates glycosylation, but its role in tumors has not been determined. Here, we showed that high CHSY3 expression promotes proliferation in gastric cancer (GC) cells and is associated with poor prognosis in GC patients. We analyzed the immunohistochemistry data of 150 gastric cancer patients to determine the clinicopathological and survival significance of CHSY3. Immunofluorescence was used to detect the colocalization of CHSY3 with infiltrating immune cells. Additionally, CHSY3 was predominantly found in tumor tissues and showed higher abundance compared to matched adjacent tissues. High CHSY3 expression was associated with more advanced tumor stage, higher recurrence risk and worse survival. Immunohistochemistry and bioinformatic analysis revealed that CHSY3 expression was significantly positively correlated with tumor-associated macrophage (TAM) infiltration. Moreover, after knocking down CHSY3, the proliferation of cells was decreased, and the migration ability was reduced, as shown by scratch, monoclonal and transwell assays. In conclusion, this study revealed that CHSY3 has a tumor-promoting effect on GC, suggesting a novel therapeutic strategy against this disease. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1664-3224 |
Relation: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1364979/full; https://doaj.org/toc/1664-3224 |
DOI: | 10.3389/fimmu.2024.1364979 |
URL الوصول: | https://doaj.org/article/1f5d065bd32c4672970c02a194e7c1d4 |
رقم الأكسشن: | edsdoj.1f5d065bd32c4672970c02a194e7c1d4 |
قاعدة البيانات: | Directory of Open Access Journals |
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