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OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels

التفاصيل البيبلوغرافية
العنوان: OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels
المؤلفون: Swetha E Murthy, Adrienne E Dubin, Tess Whitwam, Sebastian Jojoa-Cruz, Stuart M Cahalan, Seyed Ali Reza Mousavi, Andrew B Ward, Ardem Patapoutian
المصدر: eLife, Vol 7 (2018)
بيانات النشر: eLife Sciences Publications Ltd, 2018.
سنة النشر: 2018
المجموعة: LCC:Medicine
LCC:Science
LCC:Biology (General)
مصطلحات موضوعية: mechanotransduction, ion channels, OSCA, mechanically activated, Medicine, Science, Biology (General), QH301-705.5
الوصف: Mechanically activated (MA) ion channels convert physical forces into electrical signals, and are essential for eukaryotic physiology. Despite their importance, few bona-fide MA channels have been described in plants and animals. Here, we show that various members of the OSCA and TMEM63 family of proteins from plants, flies, and mammals confer mechanosensitivity to naïve cells. We conclusively demonstrate that OSCA1.2, one of the Arabidopsis thaliana OSCA proteins, is an inherently mechanosensitive, pore-forming ion channel. Our results suggest that OSCA/TMEM63 proteins are the largest family of MA ion channels identified, and are conserved across eukaryotes. Our findings will enable studies to gain deep insight into molecular mechanisms of MA channel gating, and will facilitate a better understanding of mechanosensory processes in vivo across plants and animals.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2050-084X
Relation: https://elifesciences.org/articles/41844; https://doaj.org/toc/2050-084X
DOI: 10.7554/eLife.41844
URL الوصول: https://doaj.org/article/21be4628362d442387f027bc248cfc59
رقم الأكسشن: edsdoj.21be4628362d442387f027bc248cfc59
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2050084X
DOI:10.7554/eLife.41844