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Human articular cartilage repair: Sources and detection of cytotoxicity and genotoxicity in photo‐crosslinkable hydrogel bioscaffolds

التفاصيل البيبلوغرافية
العنوان: Human articular cartilage repair: Sources and detection of cytotoxicity and genotoxicity in photo‐crosslinkable hydrogel bioscaffolds
المؤلفون: Cheryl Lee, Cathal D. O'Connell, Carmine Onofrillo, Peter F. M. Choong, Claudia Di Bella, Serena Duchi
المصدر: Stem Cells Translational Medicine, Vol 9, Iss 3, Pp 302-315 (2020)
بيانات النشر: Oxford University Press, 2020.
سنة النشر: 2020
المجموعة: LCC:Medicine (General)
LCC:Cytology
مصطلحات موضوعية: adult stem cells, arthritis, cytotoxic agents, tissue engineering, tissue regeneration, Medicine (General), R5-920, Cytology, QH573-671
الوصف: Abstract Three‐dimensional biofabrication using photo‐crosslinkable hydrogel bioscaffolds has the potential to revolutionize the need for transplants and implants in joints, with articular cartilage being an early target tissue. However, to successfully translate these approaches to clinical practice, several barriers must be overcome. In particular, the photo‐crosslinking process may impact on cell viability and DNA integrity, and consequently on chondrogenic differentiation. In this review, we primarily explore the specific sources of cellular cytotoxicity and genotoxicity inherent to the photo‐crosslinking reaction, the methods to analyze cell death, cell metabolism, and DNA damage within the bioscaffolds, and the possible strategies to overcome these detrimental effects.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2157-6580
2157-6564
Relation: https://doaj.org/toc/2157-6564; https://doaj.org/toc/2157-6580
DOI: 10.1002/sctm.19-0192
URL الوصول: https://doaj.org/article/22f7d2dc05cf4ecebdfc337a723e68d1
رقم الأكسشن: edsdoj.22f7d2dc05cf4ecebdfc337a723e68d1
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:21576580
21576564
DOI:10.1002/sctm.19-0192