دورية أكاديمية
Automatic amperometric titration method for quantitative determination of zinc oxide in ointments
| العنوان: | Automatic amperometric titration method for quantitative determination of zinc oxide in ointments |
|---|---|
| المؤلفون: | Vasile Oprea, Vladimir Valica, Constantin Cheptanaru, Mihai Nistorica, Serghei Oprea, Liviu Movila |
| المصدر: | The Moldovan Medical Journal, Vol 63, Iss 1, Pp 13-18 (2020) |
| بيانات النشر: | Scientific Medical Association of Moldova, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | automatic amperometric titration, zinc oxide, quantitative determination of zn, Medicine |
| الوصف: | Background: Zinc is an important trace mineral in human body, therefore development of new methods for zinc determination in drugs is an actual task. Material and methods: Assay of standard solutions of zinc ions and solutions of ointments to be analyzed was performed automatically using the titrator TITRION, which recorded, then displayed on the screen each amperometric titration curve. The titration curves had a sudden break in the current intensity at the equivalence point, caused by anodic oxidation of the titrant and cathodic reduction of H+ at pH 3 – 4. The stoichiometry of Zn2+ ion sedimentation reaction with [Fe(CN)6 ]4- ions was studied and confirmed in the presence of the background electrolyte and the ZnO calculation formulas in the analyzed ointments were deduced. Results: Two different ointment masses were weighed for the Zoxitin ointment and the separate calculation results were 0.4172±0.0051 g/g and 0.4212±0.0051 g/g of ointment, and in the zinc oxide ointment ω(ZnO) was 10.208±0.078 %.These results were compared with the results of ZnO analysis in ointment by the classical complexometric titration method. For the Zoxitin ointment m(ZnO) was 0.4223±0.007 g/g of ointment, and for the ointment with ZnO ω(ZnO) was 10.18±0.11%. Conclusions: An automatic amperometric titration method was developed to quantify ZnO in ointments. The method is based on the sedimentation reaction of zinc ions with potassium ferrocyanide solution in presence of acetate buffer solution as background electrolyte. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2537-6373 2537-6381 |
| Relation: | http://moldmedjournal.md/wp-content/uploads/2020/03/moldovan-med-j-2020-63-1-oprea-et-al-full-text.pdf; https://doaj.org/toc/2537-6373; https://doaj.org/toc/2537-6381 |
| DOI: | 10.5281/zenodo.3685650 |
| URL الوصول: | https://doaj.org/article/249d01a1cce640a2b3464d538a25a7aa |
| رقم الأكسشن: | edsdoj.249d01a1cce640a2b3464d538a25a7aa |
| قاعدة البيانات: | Directory of Open Access Journals |
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