دورية أكاديمية
Integrating RNA-Seq with GWAS reveals novel insights into the molecular mechanism underpinning ketosis in cattle
| العنوان: | Integrating RNA-Seq with GWAS reveals novel insights into the molecular mechanism underpinning ketosis in cattle |
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| المؤلفون: | Ze Yan, Hetian Huang, Ellen Freebern, Daniel J. A. Santos, Dongmei Dai, Jingfang Si, Chong Ma, Jie Cao, Gang Guo, George E. Liu, Li Ma, Lingzhao Fang, Yi Zhang |
| المصدر: | BMC Genomics, Vol 21, Iss 1, Pp 1-12 (2020) |
| بيانات النشر: | BMC, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Biotechnology LCC:Genetics |
| مصطلحات موضوعية: | GWAS, Holstein, Ketosis, RNA-Seq, Phe-WAS, WGCNA, Biotechnology, TP248.13-248.65, Genetics, QH426-470 |
| الوصف: | Abstract Background Ketosis is a common metabolic disease during the transition period in dairy cattle, resulting in long-term economic loss to the dairy industry worldwide. While genetic selection of resistance to ketosis has been adopted by many countries, the genetic and biological basis underlying ketosis is poorly understood. Results We collected a total of 24 blood samples from 12 Holstein cows, including 4 healthy and 8 ketosis-diagnosed ones, before (2 weeks) and after (5 days) calving, respectively. We then generated RNA-Sequencing (RNA-Seq) data and seven blood biochemical indicators (bio-indicators) from leukocytes and plasma in each of these samples, respectively. By employing a weighted gene co-expression network analysis (WGCNA), we detected that 4 out of 16 gene-modules, which were significantly engaged in lipid metabolism and immune responses, were transcriptionally (FDR |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1471-2164 |
| Relation: | http://link.springer.com/article/10.1186/s12864-020-06909-z; https://doaj.org/toc/1471-2164 |
| DOI: | 10.1186/s12864-020-06909-z |
| URL الوصول: | https://doaj.org/article/2504a9908d0f4f2084b19e205efbfe45 |
| رقم الأكسشن: | edsdoj.2504a9908d0f4f2084b19e205efbfe45 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 14712164 |
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| DOI: | 10.1186/s12864-020-06909-z |