دورية أكاديمية
Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma
العنوان: | Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma |
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المؤلفون: | Sarah A. Best, Sheryl Ding, Ariena Kersbergen, Xueyi Dong, Ji-Ying Song, Yi Xie, Boris Reljic, Kaiming Li, James E. Vince, Vivek Rathi, Gavin M. Wright, Matthew E. Ritchie, Kate D. Sutherland |
المصدر: | Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
بيانات النشر: | Nature Portfolio, 2019. |
سنة النشر: | 2019 |
المجموعة: | LCC:Science |
مصطلحات موضوعية: | Science |
الوصف: | Lung adenocarcinomas frequently harbour KRAS mutations, of which a subset are characterized by co-mutation of KEAP1. Here the authors show, in mice, that Kras G12D mutant tumours are metabolically distinct, with a bronchiolar cell-of-origin. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2041-1723 |
Relation: | https://doaj.org/toc/2041-1723 |
DOI: | 10.1038/s41467-019-12164-y |
URL الوصول: | https://doaj.org/article/ac2538b3a39145fe917c923569a787a5 |
رقم الأكسشن: | edsdoj.2538b3a39145fe917c923569a787a5 |
قاعدة البيانات: | Directory of Open Access Journals |
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