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Bioactive constituents of Salvia przewalskii and the molecular mechanism of its antihypoxia effects determined using quantitative proteomics

التفاصيل البيبلوغرافية
العنوان: Bioactive constituents of Salvia przewalskii and the molecular mechanism of its antihypoxia effects determined using quantitative proteomics
المؤلفون: Yafeng Wang, Delong Duo, Yingjun Yan, Rongyue He, Shengbiao Wang, Aixia Wang, Xinan Wu
المصدر: Pharmaceutical Biology, Vol 58, Iss 1, Pp 469-477 (2020)
بيانات النشر: Taylor & Francis Group, 2020.
سنة النشر: 2020
المجموعة: LCC:Therapeutics. Pharmacology
مصطلحات موضوعية: oxidoreduction systems, fructose metabolism, salvia przewalskii, Therapeutics. Pharmacology, RM1-950
الوصف: Context Environmental hypobaric hypoxia induces several physiological or pathological responses in individuals in high-altitude regions. Salvia przewalskii Maxim (Labiatae) (SPM) is a traditional Chinese herbal medicine and has known antibacterial, antiviral, antioxidant, anti-thrombotic, and anti-depressant activities. Objective This study examined the antihypoxia effects of SPM in vivo. Materials and methods The dried and pulverised of SPM was extracted from root crude drug with 70% ethanol with ultrasound. Male Sprague-Dawley rats were divided into three groups (n = 10): normal group, hypoxia group (altitude of 4260 m), and hypoxia + SPM group (altitude of 4260 m, SPM of 1.0 g/kg/day). The experiment persisted for 4 weeks. The mean pulmonary arterial pressure (mPAP), hypoxia-inducible factor-1α (HIF-1α) mRNA, and lung pathology were analysed using pulmonary artery pressure recorder, quantitative polymerase chain reaction, and histopathological analysis. Moreover, the effects of SPM on lung proteomes during hypoxia were observed by a TMT-based proteomic approach. Results Pre-treatment with SPM decreased mPAP (24.86%) and HIF-1α (31.24%), and attenuated the pathological changes in lung tissues. In addition, a total of 28 proteins were differentially expressed in lung of hypoxia + SPM group (fold change > ± 1.2 and p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1388-0209
1744-5116
13880209
Relation: https://doaj.org/toc/1388-0209; https://doaj.org/toc/1744-5116
DOI: 10.1080/13880209.2020.1762668
URL الوصول: https://doaj.org/article/25ffed51825f490bb8c0991e5076de45
رقم الأكسشن: edsdoj.25ffed51825f490bb8c0991e5076de45
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:13880209
17445116
DOI:10.1080/13880209.2020.1762668