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Grating-based X-ray Dark-field Computed Tomography of Living Mice

التفاصيل البيبلوغرافية
العنوان: Grating-based X-ray Dark-field Computed Tomography of Living Mice
المؤلفون: A. Velroyen, A. Yaroshenko, D. Hahn, A. Fehringer, A. Tapfer, M. Müller, P.B. Noël, B. Pauwels, A. Sasov, A.Ö. Yildirim, O. Eickelberg, K. Hellbach, S.D. Auweter, F.G. Meinel, M.F. Reiser, M. Bech, F. Pfeiffer
المصدر: EBioMedicine, Vol 2, Iss 10, Pp 1500-1506 (2015)
بيانات النشر: Elsevier, 2015.
سنة النشر: 2015
المجموعة: LCC:Medicine
LCC:Medicine (General)
مصطلحات موضوعية: Dark-field imaging, Dark-field computed tomography, Pulmonary emphysema, Pulmonary fibrosis, X-ray phase-contrast imaging, Medicine, Medicine (General), R5-920
الوصف: Changes in x-ray attenuating tissue caused by lung disorders like emphysema or fibrosis are subtle and thus only resolved by high-resolution computed tomography (CT). The structural reorganization, however, is of strong influence for lung function. Dark-field CT (DFCT), based on small-angle scattering of x-rays, reveals such structural changes even at resolutions coarser than the pulmonary network and thus provides access to their anatomical distribution. In this proof-of-concept study we present x-ray in vivo DFCTs of lungs of a healthy, an emphysematous and a fibrotic mouse. The tomographies show excellent depiction of the distribution of structural – and thus indirectly functional – changes in lung parenchyma, on single-modality slices in dark field as well as on multimodal fusion images. Therefore, we anticipate numerous applications of DFCT in diagnostic lung imaging. We introduce a scatter-based Hounsfield Unit (sHU) scale to facilitate comparability of scans. In this newly defined sHU scale, the pathophysiological changes by emphysema and fibrosis cause a shift towards lower numbers, compared to healthy lung tissue.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2352-3964
Relation: http://www.sciencedirect.com/science/article/pii/S2352396415301079; https://doaj.org/toc/2352-3964
DOI: 10.1016/j.ebiom.2015.08.014
URL الوصول: https://doaj.org/article/a264009a61de4702afe32fd292d13dd7
رقم الأكسشن: edsdoj.264009a61de4702afe32fd292d13dd7
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23523964
DOI:10.1016/j.ebiom.2015.08.014