دورية أكاديمية
MiR‐10a‐5p restrains the aggressive phenotypes of ovarian cancer cells by inhibiting HOXA1
| العنوان: | MiR‐10a‐5p restrains the aggressive phenotypes of ovarian cancer cells by inhibiting HOXA1 |
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| المؤلفون: | Li‐Jun Liu, Xiao‐Yan Sun, Chen‐Xi Yang, Xiao‐Yan Zou |
| المصدر: | Kaohsiung Journal of Medical Sciences, Vol 37, Iss 4, Pp 276-285 (2021) |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | HOXA1, invasion, migration, miR‐10a‐5p, ovarian cancer, Medicine (General), R5-920 |
| الوصف: | Abstract MicroRNAs (miRNAs) are dysregulated in human ovarian carcinoma (OC). But the mechanism underlying miR‐10a‐5p in regulating the progression of OC need deeply explored. In the current study, we observed that miR‐10a‐5p was down‐expressed in OC samples and OC cell lines. In addition, miR‐10a‐5p restrained the viability, colony formation, migration ability and invasiveness of OC cells. We further ascertained Homeobox A1 (HOXA1) was a downstream gene of miR‐10a‐5p. Furthermore, HOXA1 was distinctly upregulated in OC samples. Finally, upregulation of HOXA1 abolished the suppressive effects of miR‐10a‐5p on OC cells. These observations suggested that miR‐10a‐5p suppressed the aggressive phenotypes of OC cells via regulating HOXA1. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2410-8650 1607-551X |
| Relation: | https://doaj.org/toc/1607-551X; https://doaj.org/toc/2410-8650 |
| DOI: | 10.1002/kjm2.12335 |
| URL الوصول: | https://doaj.org/article/d270dc0509db45fa88a099368401fc02 |
| رقم الأكسشن: | edsdoj.270dc0509db45fa88a099368401fc02 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24108650 1607551X |
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| DOI: | 10.1002/kjm2.12335 |