التفاصيل البيبلوغرافية
العنوان:
A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition
المؤلفون:
Christopher E. Mahoney , David Pirman , Victor Chubukov , Taryn Sleger , Sebastian Hayes , Zi Peng Fan , Eric L. Allen , Ying Chen , Lingling Huang , Meina Liu , Yingjia Zhang , Gabrielle McDonald , Rohini Narayanaswamy , Sung Choe , Yue Chen , Stefan Gross , Giovanni Cianchetta , Anil K. Padyana , Stuart Murray , Wei Liu , Kevin M. Marks , Joshua Murtie , Marion Dorsch , Shengfang Jin , Nelamangala Nagaraja , Scott A. Biller , Thomas Roddy , Janeta Popovici-Muller , Gromoslaw A. Smolen
المصدر:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
بيانات النشر:
Nature Portfolio, 2019.
سنة النشر:
2019
المجموعة:
LCC:Science
مصطلحات موضوعية:
Science
الوصف:
Cancer cells are metabolically adaptable and the identification of specific vulnerabilities is challenging. Here the authors identify a subset of neuroendocrine cell lines exquisitely sensitive to inhibition of SQLE, an enzyme in the cholesterol biosynthetic pathway, due to the toxic accumulation of pathway intermediate squalene.
نوع الوثيقة:
article
وصف الملف:
electronic resource
اللغة:
English
تدمد:
2041-1723
Relation:
https://doaj.org/toc/2041-1723
DOI:
10.1038/s41467-018-07959-4
URL الوصول:
https://doaj.org/article/27aeab8f4bce40e788924435c21f0b77
رقم الأكسشن:
edsdoj.27aeab8f4bce40e788924435c21f0b77
قاعدة البيانات:
Directory of Open Access Journals
Full Text Finder