دورية أكاديمية
Long-term Neurologic Outcome After Spinal Ependymoma Resection With Multimodal Intraoperative Electrophysiological Recording: Cohort Study and Review of the Literature
| العنوان: | Long-term Neurologic Outcome After Spinal Ependymoma Resection With Multimodal Intraoperative Electrophysiological Recording: Cohort Study and Review of the Literature |
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| المؤلفون: | Grégoire P. Chatain, Michael W. Kortz, Stephanie Serva, Keshari Shrestha, Patrick Hosokawa, Timothy H. Ung, Michael Finn |
| المصدر: | Neurospine, Vol 19, Iss 1, Pp 118-132 (2022) |
| بيانات النشر: | Korean Spinal Neurosurgery Society, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: | spinal ependymoma, intraoperative neuromonitoring, neurological outcome, mccormick scale, case series, literature review, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Objective To evaluate how multimodal intraoperative neuromonitoring (IONM) changes during spinal ependymoma (SE) resection correlate with long-term neuro-functional outcomes. Methods A retrospective analysis of patients aged 18 years or older who underwent surgical resection for SE over a 10-year period was conducted. IONM changes were defined as sustained transcranial motor evoked potential (TcMEP) and/or somatosensory evoked potential (SSEP) signal decrease of 50% or greater from baseline. Primary endpoints were postoperative modified McCormick Neurologic Scale (MNS) scores at postoperative day (POD) < 2, 6 weeks, 1 year, and 2 years. Univariate and multivariate analyses were performed. Results Twenty-nine patients were identified. Average age was 44.2±15.4 years. Sixteen (55.2%) were male and 13 (44.8%) were female. Tumor location was 10 cervical-predominant (34.5%), 13 thoracic-predominant (44.8%), and 6 lumbar/conus-predominant (20.7%). A majority (69.0%) were World Health Organization grade 2 tumors. Twentyfour patients (82.8%) achieved gross total resection. Thirteen patients (44.8%) had a sustained documented IONM signal change and 10 (34.5%) had a TcMEP change with or without derangement in SSEP. At POD < 2, 6 weeks, 1 year, and 2 years, MNS was significantly higher for those when analyzing subgroups with either any sustained IONM or TcMEP±SSEP signal attenuation > 50% below baseline (all p 50% below baseline, particularly for TcMEP, are significantly associated with higher MNS postoperatively out to 2 years. Intraoperative and postoperative management of these patients warrant special consideration to limit neurologic morbidity. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2586-6583 2586-6591 |
| Relation: | http://www.e-neurospine.org/upload/pdf/ns-2143200-600.pdf; https://doaj.org/toc/2586-6583; https://doaj.org/toc/2586-6591 |
| DOI: | 10.14245/ns.2143200.600 |
| URL الوصول: | https://doaj.org/article/27e576a80e9d4af086188e31e7bc41b9 |
| رقم الأكسشن: | edsdoj.27e576a80e9d4af086188e31e7bc41b9 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 25866583 25866591 |
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| DOI: | 10.14245/ns.2143200.600 |