دورية أكاديمية
Ionotropic Glutamate Receptors (iGluRs): Overview of iGluR2 ligand binding domain in complex with agonists and antagonists
| العنوان: | Ionotropic Glutamate Receptors (iGluRs): Overview of iGluR2 ligand binding domain in complex with agonists and antagonists |
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| المؤلفون: | Zorica Serafimoska, Tommy N. Johansen, Karla Frydenvang, Ljubica Suturkova |
| المصدر: | Makedonsko Farmacevtski Bilten, Vol 57, Iss (1, 2), Pp 3-16 (2011) |
| بيانات النشر: | University Ss Cyril and Methodius in Skopje, Faculty of Pharmacy and Macedonian Pharmaceutical Association, 2011. |
| سنة النشر: | 2011 |
| المجموعة: | LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | Pharmacy and materia medica, RS1-441 |
| الوصف: | Ionotropic glutamate receptors (iGluRs) constitute a family of ligand gated ion channels subdivided in three classes, NMDA, AMPA (iGluA1-4) and KA (1-5) according to the agonists that selectively activate them. iGluRs are tetrameric assemblies of highly homologous receptor subunits. They are critically important for normal brain function and are considered to be involved on neurological disorders and degenerative diseases such as schizophrenia, Alzheimer’s disease, brain damage following stroke and epilepsy. Since the first publication of the structure of recombinant soluble protein of ligand binding domain of GluA2 extensive studies on this group of receptors were performed and many crystal structures as complexes of GluA2-LBD with agonists, partial agonists and antagonists were obtained. The structural information in combination with functional data makes good platform for consecutive investigation and design of new selective drugs which will be used in treatment of neurodegerative diseases. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1409-8695 1857-8969 |
| Relation: | http://bulletin.mfd.org.mk/volumes/Volume%2057/57_001.pdf; https://doaj.org/toc/1409-8695; https://doaj.org/toc/1857-8969 |
| URL الوصول: | https://doaj.org/article/d287df465a054dc0b636ab6f06e5d564 |
| رقم الأكسشن: | edsdoj.287df465a054dc0b636ab6f06e5d564 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14098695 18578969 |
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