دورية أكاديمية
Physical Activity and Epigenetic Aging in Breast Cancer Treatment
| العنوان: | Physical Activity and Epigenetic Aging in Breast Cancer Treatment |
|---|---|
| المؤلفون: | Chantalle Moulton, Elisa Grazioli, José Santiago Ibáñez-Cabellos, Arianna Murri, Claudia Cerulli, Monica Silvestri, Daniela Caporossi, Federico V. Pallardó, José Luis García-Giménez, Stefano Magno, Cristina Rossi, Guglielmo Duranti, Salvador Mena-Molla, Attilio Parisi, Ivan Dimauro |
| المصدر: | International Journal of Molecular Sciences, Vol 25, Iss 16, p 8596 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | DNA methylation, epigenetic clock, exercise, telomere, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Biological age, reflecting the cumulative damage in the body over a lifespan, is a dynamic measure more indicative of individual health than chronological age. Accelerated aging, when biological age surpasses chronological age, is implicated in poorer clinical outcomes, especially for breast cancer (BC) survivors undergoing treatments. This preliminary study investigates the impact of a 16-week online supervised physical activity (PA) intervention on biological age in post-surgery female BC patients. Telomere length was measured using qPCR, and the ELOVL2-based epigenetic clock was assessed via DNA methylation pyrosequencing of the ELOVL2 promoter region. Telomere length remained unchanged, but the ELOVL2 epigenetic clock indicated a significant decrease in biological age in the PA group, suggesting the potential of PA interventions to reverse accelerated aging processes in BC survivors. The exercise group showed improved cardiovascular fitness, highlighting PA’s health impact. Finally, the reduction in biological age, as measured by the ELOVL2 epigenetic clock, was significantly associated with improvements in cardiovascular fitness and handgrip strength, supporting improved recovery. Epigenetic clocks can potentially assess health status and recovery progress in BC patients, identifying at-risk individuals in clinical practice. This study provides potential and valuable insights into how PA benefits BC survivors’ health, supporting the immediate benefits of a 16-week exercise intervention in mitigating accelerated aging. The findings could suggest a holistic approach to improving the health and recovery of post-surgery BC patients. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/25/16/8596; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms25168596 |
| URL الوصول: | https://doaj.org/article/295c33e700a34b0a8d7046e987681cc6 |
| رقم الأكسشن: | edsdoj.295c33e700a34b0a8d7046e987681cc6 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
|---|---|
| DOI: | 10.3390/ijms25168596 |