دورية أكاديمية
Umbilical cord blood plasma-derived exosomes as a novel therapy to reverse liver fibrosis
| العنوان: | Umbilical cord blood plasma-derived exosomes as a novel therapy to reverse liver fibrosis |
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| المؤلفون: | Yu-Jen Huang, Jerry Cao, Chih-Yuan Lee, Yao-Ming Wu |
| المصدر: | Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-13 (2021) |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine (General) LCC:Biochemistry |
| مصطلحات موضوعية: | Cirrhosis, Exosomes, Hepatic stellate cells, Inhibitor of DNA binding 1, Medicine (General), R5-920, Biochemistry, QD415-436 |
| الوصف: | Abstract Background Cirrhosis is a chronic liver disease whereby scar tissue replaces healthy liver parenchyma, leading to disruption of the liver architecture and hepatic dysfunction. Currently, there is no effective disease-modifying therapy for liver fibrosis. Recently, our group demonstrated that human umbilical cord blood (UCB) plasma possesses therapeutic effects in a rat model of acute liver failure. Methods In the current study, we tested whether exosomes (Exo) existed in UCB plasma and if they produced any antifibrotic benefits in a liver fibrosis model. Results Our results showed that UCB-Exo improved liver function and increased matrix metalloproteinase/tissue inhibitor of metalloproteinase degradation to reduce the degree of fibrosis. Moreover, UCB-Exo were found to suppress hepatic stellate cell (HSC) activity in vitro. These effects were associated with suppression of transforming growth factor-β/inhibitor of DNA binding 1 signaling. Conclusions These results further support that UCB-Exo have antifibrotic effects in mice with liver fibrosis and activated HSCs and may herald a new cell-free antifibrotic therapy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1757-6512 |
| Relation: | https://doaj.org/toc/1757-6512 |
| DOI: | 10.1186/s13287-021-02641-x |
| URL الوصول: | https://doaj.org/article/2a67964002e94c2e88009bbbf85cdeca |
| رقم الأكسشن: | edsdoj.2a67964002e94c2e88009bbbf85cdeca |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 17576512 |
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| DOI: | 10.1186/s13287-021-02641-x |