دورية أكاديمية
Using machine learning to predict five-year transplant-free survival among infants with hypoplastic left heart syndrome
| العنوان: | Using machine learning to predict five-year transplant-free survival among infants with hypoplastic left heart syndrome |
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| المؤلفون: | Andrew H. Smith, Geoffrey M. Gray, Awais Ashfaq, Alfred Asante-Korang, Mohamed A. Rehman, Luis M. Ahumada |
| المصدر: | Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024) |
| بيانات النشر: | Nature Portfolio, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Cardiovascular Surgical Procedures, Heart Defects, Congenital, Intensive Care Units, Pediatric, Infant, Medicine, Science |
| الوصف: | Abstract Hypoplastic left heart syndrome (HLHS) is a congenital malformation commonly treated with palliative surgery and is associated with significant morbidity and mortality. Risk stratification models have often relied upon traditional survival analyses or outcomes data failing to extend beyond infancy. Individualized prediction of transplant-free survival (TFS) employing machine learning (ML) based analyses of outcomes beyond infancy may provide further valuable insight for families and healthcare providers along the course of a staged palliation. Data from both the Pediatric Heart Network (PHN) Single Ventricle Reconstruction (SVR) trial and Extension study (SVR II), which extended cohort follow up for five years was used to develop ML-driven models predicting TFS. Models incrementally incorporated features corresponding to successive phases of care, from pre-Stage 1 palliation (S1P) through the stage 2 palliation (S2P) hospitalization. Models trained with features from Pre-S1P, S1P operation, and S1P hospitalization all demonstrated time-dependent area under the curves (td-AUC) beyond 0.70 through 5 years following S1P, with a model incorporating features through S1P hospitalization demonstrating particularly robust performance (td-AUC 0.838 (95% CI 0.836–0.840)). Machine learning may offer a clinically useful alternative means of providing individualized survival probability predictions, years following the staged surgical palliation of hypoplastic left heart syndrome. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-024-55285-1 |
| URL الوصول: | https://doaj.org/article/c2cec0b5f3d8465aa6532c9d30ce9e7a |
| رقم الأكسشن: | edsdoj.2cec0b5f3d8465aa6532c9d30ce9e7a |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-024-55285-1 |