دورية أكاديمية
Comparison of protective effect of ordinary Cordyceps militaris and selenium-enriched Cordyceps militaris on triptolide-induced acute hepatotoxicity and the potential mechanisms
| العنوان: | Comparison of protective effect of ordinary Cordyceps militaris and selenium-enriched Cordyceps militaris on triptolide-induced acute hepatotoxicity and the potential mechanisms |
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| المؤلفون: | Lan Wang, Qiong-hui Huang, Yan-feng Huang, Jian-hui Xie, Chang Qu, Jian-ping Chen, Lin Zheng, Tie-gang Yi, Hui-fang Zeng, Hui-lin Li |
| المصدر: | Journal of Functional Foods, Vol 46, Iss , Pp 365-377 (2018) |
| بيانات النشر: | Elsevier, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Nutrition. Foods and food supply |
| مصطلحات موضوعية: | Selenium-enriched Cordyceps militaris, Triptolide, Hepatotoxicity, Antioxidative, Nrf2 pathway, Anti-apoptosis, Nutrition. Foods and food supply, TX341-641 |
| الوصف: | This study aimed to investigate the prophylactic effect of selenium-enriched Cordyceps militaris (CS) against triptolide-induced acute hepatotoxicity. Rats were intragastrically administrated with CS and ordinary Cordyceps militaris (CM) for 7 consecutive days prior to triptolide intoxication. Triptolide elevated levels of serum aminotransferases, total cholesterol and caused severe liver injury. However, CS remarkably inhibited the increases of these parameters and pathological damages. The action mechanisms might be associated with its antioxidant property by enhancing antioxidant enzymes activities and triggering nuclear factor E2-related factor 2 (Nrf2) translocation and downstream genes expression. Besides, CS prevented cellular apoptosis through up-regulating Bcl-2/Bax ratio and down-regulating cytochrome c and caspase-3 cleavage. Constituent analyses showed that CS had higher amounts of cordycepin, selenium, selenocystine and polysaccharides than CM. In conclusion, CS effectively prevented triptolide-induced hepatotoxicity via activating Nrf2 pathway and inhibiting hepatocyte apoptosis, suggesting that it could be a promising hepatic protector and a befitting nutraceutical supplement. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1756-4646 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S1756464618302330; https://doaj.org/toc/1756-4646 |
| DOI: | 10.1016/j.jff.2018.05.016 |
| URL الوصول: | https://doaj.org/article/300363d87c7c4f729933484b7d5f2a5e |
| رقم الأكسشن: | edsdoj.300363d87c7c4f729933484b7d5f2a5e |
| قاعدة البيانات: | Directory of Open Access Journals |
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