دورية أكاديمية
Triglyceride-glucose index is an independent predictor of coronary artery calcification progression in patients with chronic kidney disease
| العنوان: | Triglyceride-glucose index is an independent predictor of coronary artery calcification progression in patients with chronic kidney disease |
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| المؤلفون: | Ye Eun Ko, Hyung Woo Kim, Jung Tak Park, Seung Hyeok Han, Shin-Wook Kang, Suah Sung, Kyu-Beck Lee, Joongyub Lee, Kook-Hwan Oh, Tae-Hyun Yoo |
| المصدر: | Kidney Research and Clinical Practice, Vol 43, Iss 3, Pp 381-390 (2024) |
| بيانات النشر: | The Korean Society of Nephrology, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Internal medicine LCC:Specialties of internal medicine |
| مصطلحات موضوعية: | cardiovascular disease, chronic, coronary artery calcification, renal insufficiency, insulin resistance, triglyceride-glucose index, Internal medicine, RC31-1245, Specialties of internal medicine, RC581-951 |
| الوصف: | Background Coronary artery calcification (CAC) is highly prevalent in patients with chronic kidney disease (CKD) and is associated with major adverse cardiovascular events and metabolic disturbances. The triglyceride-glucose index (TyGI), a novel surrogate marker of metabolic syndrome and insulin resistance, is associated with CAC in the general population and in patients with diabetes. This study investigated the association between the TyGI and CAC progression in patients with CKD, which is unknown. Methods A total of 1,154 patients with CKD (grades 1–5; age, 52.8 ± 11.9 years; male, 688 [59.6%]) were enrolled from the KNOW-CKD (KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease). The TyGI was calculated as follows: ln (fasting triglycerides × fasting glucose/2). Patients were classified into tertiles (low, intermediate, high) based on the TyGI. The primary outcome was annualized percentage change in CAC score [(percent change in CAC score + 1)12/follow-up months – 1] of ≥15%, defined as CAC progression. Results During the 4-year follow-up, the percentage of patients with CAC progression increased across TyGI groups (28.6%, 37.5%, and 46.2% in low, intermediate, and high groups, respectively; p < 0.001). A high TyGI was associated with an increased risk of CAC progression (odds ratio [OR], 2.11; 95% confidence interval [CI], 1.14–3.88; p = 0.02) compared to the low group. Moreover, a 1-point increase in the TyGI was related to increased risk of CAC progression (OR, 1.55; 95% CI, 1.06–1.76; p = 0.02) after adjustment. Conclusion A high TyGI may be a useful predictor of CAC progression in CKD. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Korean |
| تدمد: | 2211-9132 2211-9140 |
| Relation: | http://www.krcp-ksn.org/upload/pdf/j-krcp-23-264.pdf; https://doaj.org/toc/2211-9132; https://doaj.org/toc/2211-9140 |
| DOI: | 10.23876/j.krcp.23.264 |
| URL الوصول: | https://doaj.org/article/30a81b455f394987a0847e951226f5c8 |
| رقم الأكسشن: | edsdoj.30a81b455f394987a0847e951226f5c8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22119132 22119140 |
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| DOI: | 10.23876/j.krcp.23.264 |