دورية أكاديمية
Validation of the cough phenotype TBQ among elderly Finnish subjects
| العنوان: | Validation of the cough phenotype TBQ among elderly Finnish subjects |
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| المؤلفون: | Heikki O. Koskela, Johanna T. Kaulamo, Tuomas A. Selander, Anne M. Lätti |
| المصدر: | ERJ Open Research, Vol 8, Iss 4 (2022) |
| بيانات النشر: | European Respiratory Society, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Medicine |
| الوصف: | Background Phenotypes can be utilised in the clinical management of disorders. Approaches to phenotype disorders have evolved from subjective expert opinion to data-driven methodologies. A previous cluster analysis among working-age subjects with cough revealed a phenotype TBQ (triggers, background disorders, quality-of-life impairment), which included 38% of the subjects with cough. The present study was carried out to validate this phenotyping among elderly, retired subjects with cough. Methods This was an observational cross-sectional study conducted via email among the members of the Finnish Pensioners’ Federation (n=26 205, 23.6% responded). The analysis included 1109 subjects with current cough (mean±sd age 72.9±5.3 years; 67.7% female). All filled in a comprehensive 86-item questionnaire including the Leicester Cough Questionnaire. Phenotypes were identified utilising k-means partitional clustering. Results Two clusters were identified. Cluster A included 75.2% of the subjects and cluster B 24.8% of the subjects. The three most important variables to separate the clusters were the number of cough triggers (mean±sd 2.47±2.34 versus 7.08±3.16, respectively; p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2312-0541 23120541 |
| Relation: | http://openres.ersjournals.com/content/8/4/00284-2022.full; https://doaj.org/toc/2312-0541 |
| DOI: | 10.1183/23120541.00284-2022 |
| URL الوصول: | https://doaj.org/article/30f972e8a97b47e7ab5184596a04b9e3 |
| رقم الأكسشن: | edsdoj.30f972e8a97b47e7ab5184596a04b9e3 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23120541 |
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| DOI: | 10.1183/23120541.00284-2022 |